Adjei Raymond Lovelace, Adomako Lady Asantewah Boamah, Korang-Labi Appiah, Avornyo Franklin Kodzo, Timire Collins, Larbi Rita Ohene, Kubasari Cletus, Ackon Stephen E D, Reid Anthony
Council for Scientific and Industrial Research-Animal Research Institute, Accra P.O. Box AH 20, Ghana.
Council for Scientific and Industrial Research-Water Research Institute, Accra P.O. Box AH 38, Ghana.
Trop Med Infect Dis. 2023 Aug 28;8(9):427. doi: 10.3390/tropicalmed8090427.
Wastewater treatment plants are efficient in reducing bacterial loads but are also considered potential drivers of environmental antimicrobial resistance (AMR). In this study, we determined the effect of increased influent wastewater volume (from 40% to 66%) in the Legon sewage treatment plant (STP) on the removal of from sewage, along with changes in AMR profiles. This before and after study compared loads and AMR patterns in influent and effluent samples from a published baseline study (January-June 2018) with a follow-up study (March-May 2023). Extended-spectrum beta-lactamase (ESBL) were measured pre- and post-sewage treatment during the follow-up study. The follow-up study showed 7.4% and 24% ESBL proportions in influent and effluent, respectively. In both studies, the STP was 99% efficient in reducing loads in effluents, with no significant difference ( = 0.42) between the two periods. More resistance to antimicrobials was seen in effluents in the follow-up study versus the baseline study. The increased influent capacity did not reduce the efficiency of the STP in removing from influent wastewater but was associated with increased AMR patterns in effluent water. Further studies are required to determine whether these changes have significant effects on human health.
污水处理厂在降低细菌负荷方面效率很高，但也被认为是环境中抗菌药物耐药性（AMR）的潜在驱动因素。在本研究中，我们确定了莱贡污水处理厂（STP）进水污水量增加（从40%增至66%）对污水中[具体物质未给出]去除的影响，以及抗菌药物耐药性谱的变化。这项前后对比研究将已发表的基线研究（2018年1月至6月）与后续研究（2023年3月至5月）中进水和出水样本中的[具体物质未给出]负荷及抗菌药物耐药性模式进行了比较。在后续研究中，对污水处理前后的超广谱β-内酰胺酶（ESBL）进行了检测。后续研究显示，进水和出水中ESBL的比例分别为7.4%和24%。在两项研究中，污水处理厂在降低出水[具体物质未给出]负荷方面的效率均为99%，两个时期之间无显著差异（P = 0.42）。与基线研究相比，后续研究中出水中出现了更多对抗菌药物的耐药性。进水流量增加并未降低污水处理厂从进水污水中去除[具体物质未给出]的效率，但与出水中抗菌药物耐药性模式增加有关。需要进一步研究来确定这些变化是否对人类健康有重大影响。
