Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China.
Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, China.
Clin Imaging. 2023 Nov;103:109985. doi: 10.1016/j.clinimag.2023.109985. Epub 2023 Sep 21.
Breast cancer is the most common malignant disease of women in the world. Breast cancer often metastasizes to axillary lymph nodes. Accurate assessment of the status of axillary lymph nodes is crucial to the staging and treatment of breast cancer. None of the methods used clinically for preoperative noninvasive examination of axillary lymph nodes can accurately identify cancer cells from a molecular level. In recent years, with the in-depth study of lymph node metastases, the mechanisms and molecular imaging of lymph node metastases in breast cancer have been reported. In this review, we highlight the new progress in the study of the main mechanisms of lymph node metastases in breast cancer. In addition, we analyze the advantages and disadvantages of traditional preoperative axillary lymph node imaging methods for breast cancer, and list molecular imaging methods that can accurately identify breast cancer cells in lymph nodes.
乳腺癌是全世界女性最常见的恶性疾病。乳腺癌常转移至腋窝淋巴结。准确评估腋窝淋巴结的状态对乳腺癌的分期和治疗至关重要。目前临床上用于腋窝淋巴结术前无创检查的方法均无法从分子水平准确识别癌细胞。近年来，随着对淋巴结转移机制的深入研究，乳腺癌淋巴结转移的机制和分子影像学已有报道。在这篇综述中，我们重点介绍了乳腺癌淋巴结转移主要机制研究的新进展。此外，我们分析了传统乳腺癌术前腋窝淋巴结成像方法的优缺点，并列出了可准确识别淋巴结中乳腺癌细胞的分子成像方法。
