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早发性结直肠癌：一种假说。

Early Onset Colorectal Cancer: A Hypothesis.

机构信息

Department of Medicine and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, New York, NY, USA.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

出版信息

Oncologist. 2023 Dec 11;28(12):1015-1016. doi: 10.1093/oncolo/oyad274.

DOI:10.1093/oncolo/oyad274
PMID:37758481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10712703/
Abstract

The rising rates of early onset colorectal cancer are perplexing. This commentary discusses what may be causing the increase.

摘要

早发性结直肠癌的发病率不断上升，令人费解。本文讨论了可能导致这种情况增加的原因。

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Early Onset Colorectal Cancer: A Hypothesis.早发性结直肠癌：一种假说。
Oncologist. 2023 Dec 11;28(12):1015-1016. doi: 10.1093/oncolo/oyad274.
2
Family History a Risk for Early-Onset Colorectal Cancer.家族史是结直肠癌早发的危险因素。
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The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection.早发性结直肠癌的上升趋势：流行病学、临床特征、生物学、危险因素、预防及早期检测的综合综述
Lancet Gastroenterol Hepatol. 2022 Mar;7(3):262-274. doi: 10.1016/S2468-1253(21)00426-X. Epub 2022 Jan 26.
4
Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt.DNA修复基因XRCC1的194Trp和399Gln变异等位基因的遗传与埃及早发性结直肠癌风险增加相关。
Cancer Lett. 2000 Oct 16;159(1):79-86. doi: 10.1016/s0304-3835(00)00537-1.
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Early-onset colorectal cancer: a sporadic or inherited disease?早发性结直肠癌：一种散发性疾病还是遗传性疾病？
World J Gastroenterol. 2014 Sep 21;20(35):12420-30. doi: 10.3748/wjg.v20.i35.12420.
6
Advances in Understanding Early-Onset Colorectal Cancer.理解早发性结直肠癌的进展。
Cancer Epidemiol Biomarkers Prev. 2021 Oct;30(10):1775-1777. doi: 10.1158/1055-9965.EPI-21-0844.
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High frequency of KRAS mutation in early onset colorectal adenocarcinoma: implications for pathogenesis.早期结直肠癌中KRAS突变的高频率：对发病机制的影响
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Risk factors for young-onset colorectal cancer.青年结直肠癌的危险因素。
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Addressing the rise of early-onset colorectal cancer.应对早发性结直肠癌的增多。
Lancet Gastroenterol Hepatol. 2022 Mar;7(3):197. doi: 10.1016/S2468-1253(22)00003-6. Epub 2022 Jan 31.
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Early onset sporadic colorectal cancer: Worrisome trends and oncogenic features.早发性散发性结直肠癌：令人担忧的趋势和致癌特征。
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Stress-Testing US Colorectal Cancer Screening Guidelines: Decennial Colonoscopy from Age 45 is Robust to Natural History Uncertainty and Colonoscopy Sensitivity Assumptions.对美国结直肠癌筛查指南进行压力测试：从45岁开始每十年进行一次结肠镜检查对自然病史的不确定性和结肠镜检查敏感性假设具有稳健性。
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PRKN-mediated the ubiquitination of IQGAP3 regulates cell growth, metastasis and ferroptosis in early-onset colorectal cancer.PRKN介导的IQGAP3泛素化调控早发性结直肠癌的细胞生长、转移和铁死亡。
J Bioenerg Biomembr. 2024 Dec;56(6):645-655. doi: 10.1007/s10863-024-10039-6. Epub 2024 Sep 30.

本文引用的文献

1
Colorectal cancer statistics, 2023.2023 年结直肠癌统计数据。
CA Cancer J Clin. 2023 May-Jun;73(3):233-254. doi: 10.3322/caac.21772. Epub 2023 Mar 1.
2
Burden and trend of colorectal cancer in 54 countries of Africa 2010-2019: a systematic examination for Global Burden of Disease.2010-2019 年非洲 54 个国家的结直肠癌负担和趋势：全球疾病负担的系统评估。
BMC Gastroenterol. 2022 Apr 25;22(1):204. doi: 10.1186/s12876-022-02275-0.
3
Increasing Incidence of Early-Onset Colorectal Cancer.早发性结直肠癌发病率上升。
N Engl J Med. 2022 Apr 21;386(16):1547-1558. doi: 10.1056/NEJMra2200869.
4
Epidemiology and biology of early onset colorectal cancer.早发性结直肠癌的流行病学与生物学
EXCLI J. 2022 Jan 7;21:162-182. doi: 10.17179/excli2021-4456. eCollection 2022.
5
Decreased colorectal cancer incidence and mortality in a diverse urban population with increased colonoscopy screening.结肠镜筛查增加使不同种族城市人群结直肠癌发病率和死亡率降低。
BMC Public Health. 2021 Jun 30;21(1):1280. doi: 10.1186/s12889-021-11330-6.
6
Global patterns and trends in colorectal cancer incidence in young adults.全球年轻人结直肠癌发病率的模式和趋势。
Gut. 2019 Dec;68(12):2179-2185. doi: 10.1136/gutjnl-2019-319511. Epub 2019 Sep 5.
7
Potential Intended and Unintended Consequences of Recommending Initiation of Colorectal Cancer Screening at Age 45 Years.建议在45岁开始进行结直肠癌筛查的潜在预期和非预期后果。
Gastroenterology. 2018 Oct;155(4):950-954. doi: 10.1053/j.gastro.2018.08.019. Epub 2018 Aug 21.
8
Colorectal Cancer Incidence Patterns in the United States, 1974-2013.1974 - 2013年美国结直肠癌发病模式
J Natl Cancer Inst. 2017 Aug 1;109(8). doi: 10.1093/jnci/djw322.