Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia; Central Virginia Veterans Healthcare System, Richmond, Virginia.
Center for Liver Disease Research, Departments of Inflammation and Immunity and Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio.
Gastroenterology. 2022 Oct;163(4):840-851. doi: 10.1053/j.gastro.2022.05.031. Epub 2022 May 19.
Alcohol use and consequent liver disease are major burdens that have worsened during the COVID-19 pandemic. There are several facets to the pathophysiology and clinical consequences of alcohol-use disorder (AUD) and progression to alcohol-associated liver disease (ALD) that require a concerted effort by clinicians and translational and basic science investigators. Several recent advances from bedside to bench and bench to bedside have been made in ALD. We focused this review on a case-based approach that provides a human context to these important advances across the spectrum of ALD.
饮酒和由此导致的肝脏疾病是大负担，在 COVID-19 大流行期间有所恶化。酒精使用障碍（AUD）的病理生理学和临床后果以及进展为酒精相关肝病（ALD）有几个方面，需要临床医生以及转化和基础科学研究人员共同努力。ALD 方面已经取得了一些从床边到实验室，再从实验室到床边的最新进展。我们以病例为基础的方法来重点关注这些重要进展，为 ALD 谱提供了人类背景。
