Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Metabolic Disorder, Cardiovascular and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Sci Rep. 2023 Sep 27;13(1):16259. doi: 10.1038/s41598-023-43459-2.
This study aimed to describe risk factors of severe hypoglycemia in type 2 diabetes mellitus (T2DM) patients in a tertiary care hospital in Indonesia. This study was a retrospective cohort study in the Endocrinology Outpatient Clinic of Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia. All subjects more than 18 years old who had been visiting the clinic for at least a year were included. Subjects were interviewed whether they had any severe hypoglycemia events within the past year, while data on risk factor variables of severe hypoglycemia was taken from medical records one year before data collection. We recruited 291 subjects, among whom 25.4% suffered at least one episode of severe hypoglycemia within one year. History of severe hypoglycemia (OR 5.864, p ≤ 0.001), eGFR less than 60 mL/min/1.73m (OR 1.976, p = 0.028), and insulin use (OR 2.257, p = 0.021) were associated with increased risk of severe hypoglycemia. In conclusion, history of previous severe hypoglycemia, eGFR less than 60 mL/min/1.73m, and insulin use were associated with severe hypoglycemia.
本研究旨在描述印度尼西亚一家三级保健医院 2 型糖尿病（T2DM）患者发生严重低血糖的危险因素。这是一项在印度尼西亚雅加达 Cipto Mangunkusumo 国家综合医院内分泌科门诊进行的回顾性队列研究。所有年龄在 18 岁以上、至少在诊所就诊一年的受试者均被纳入研究。对受试者进行访谈，以了解他们在过去一年中是否发生过任何严重低血糖事件，同时从收集数据前一年的病历中获取严重低血糖危险因素变量的数据。我们共招募了 291 名受试者，其中 25.4%的受试者在一年内至少发生过一次严重低血糖事件。严重低血糖史（OR 5.864，p≤0.001）、eGFR 低于 60 mL/min/1.73m（OR 1.976，p=0.028）和胰岛素使用（OR 2.257，p=0.021）与严重低血糖风险增加相关。综上所述，既往严重低血糖史、eGFR 低于 60 mL/min/1.73m 和胰岛素使用与严重低血糖相关。
