Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Department of Biophysics and Cancer Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Cells. 2023 Sep 19;12(18):2304. doi: 10.3390/cells12182304.
Riboflavin, a water-soluble vitamin B2, possesses unique biological and physicochemical properties. Its photosensitizing properties make it suitable for various biological applications, such as pathogen inactivation and photodynamic therapy. However, the effectiveness of riboflavin as a photosensitizer is hindered by its degradation upon exposure to light. The review aims to highlight the significance of riboflavin and its derivatives as potential photosensitizers for use in photodynamic therapy. Additionally, a concise overview of photodynamic therapy and utilization of blue light in dermatology is provided, as well as the photochemistry and photobiophysics of riboflavin and its derivatives. Particular emphasis is given to the latest findings on the use of acetylated 3-methyltetraacetyl-riboflavin derivative (3MeTARF) in photodynamic therapy.
核黄素，一种水溶性维生素 B2，具有独特的生物和物理化学特性。其光敏特性使其适用于各种生物应用，如病原体失活和光动力疗法。然而，核黄素作为光敏剂的效果受到其在光照下降解的限制。本综述旨在强调核黄素及其衍生物作为光动力治疗中潜在光敏剂的重要性。此外，还简要概述了光动力疗法以及在皮肤科中利用蓝光的情况，介绍了核黄素及其衍生物的光化学和光生物物理学。特别强调了最新发现的乙酰化 3-甲基四乙酰基核黄素衍生物（3MeTARF）在光动力治疗中的应用。
