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TRIM6：胶质瘤中具有预后意义和免疫相关性的上调生物标志物。

TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas.

机构信息

State Key Laboratory of Oncology in South China, Department of Gastric Surgery, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.

State Key Laboratory of Oncology in South China, Department of Thoracic Surgery, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.

出版信息

Biomolecules. 2023 Aug 24;13(9):1298. doi: 10.3390/biom13091298.

DOI:10.3390/biom13091298
PMID:37759698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10527026/
Abstract

This study investigates the expression and prognostic value of TRIM6 in gliomas, the most prevalent primary brain and spinal cord tumors. Our results show that TRIM6 is predominantly overexpressed in glioma tissues and is associated with reduced overall survival, disease-specific survival, and progression-free interval. Furthermore, TRIM6 expression is correlated with WHO grade and primary treatment outcomes. Functional analysis indicates that interactions between cytokines and their receptors play a critical role in the prognosis of glioma patients. A protein-protein interaction network reveals 10 hub genes closely linked to cytokine-cytokine receptor interaction. In vitro experiments demonstrate that silencing TRIM6 impairs the proliferation, invasion, and migration of glioma cells, while overexpressing TRIM6 enhances these abilities. Additionally, TRIM6 expression is positively associated with the abundance of innate immune cells and negatively associated with the abundance of adaptive immune cells. In summary, TRIM6 is significantly upregulated in gliomas and linked to poor prognosis, making it a potential diagnostic and prognostic biomarker. TRIM6 plays a crucial role in promoting cell viability, clonogenic potential, migration, and invasion in glioma cells. It may regulate glioma progression by modulating cytokine-cytokine receptor interaction, leading to an inflammatory response and an imbalance in immunomodulation, thereby representing a potential therapeutic target.

摘要

这项研究调查了 TRIM6 在脑胶质瘤中的表达及其预后价值，脑胶质瘤是最常见的原发性脑和脊髓肿瘤。我们的研究结果表明，TRIM6 在脑胶质瘤组织中呈高表达，且与总生存期、疾病特异性生存期和无进展生存期缩短有关。此外，TRIM6 的表达与 WHO 分级和初始治疗效果有关。功能分析表明，细胞因子及其受体的相互作用在脑胶质瘤患者的预后中起着关键作用。蛋白质-蛋白质相互作用网络揭示了 10 个与细胞因子-细胞因子受体相互作用密切相关的枢纽基因。体外实验表明，沉默 TRIM6 可损害脑胶质瘤细胞的增殖、侵袭和迁移能力，而过表达 TRIM6 则增强了这些能力。此外，TRIM6 的表达与固有免疫细胞的丰度呈正相关，与适应性免疫细胞的丰度呈负相关。总之，TRIM6 在脑胶质瘤中显著上调，并与不良预后相关，使其成为一个有潜力的诊断和预后生物标志物。TRIM6 通过调节细胞因子-细胞因子受体相互作用，在促进脑胶质瘤细胞活力、克隆形成潜力、迁移和侵袭方面发挥着重要作用，可能通过引发炎症反应和免疫调节失衡来调节脑胶质瘤的进展，从而成为一个潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/844901faf686/biomolecules-13-01298-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/340bd38981e0/biomolecules-13-01298-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/2fbd1a9f8ac8/biomolecules-13-01298-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/2eb738b0d6c4/biomolecules-13-01298-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/3c5f2cfdef28/biomolecules-13-01298-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/43e5c0f86f5f/biomolecules-13-01298-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/df596dba8d23/biomolecules-13-01298-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/06a33efec723/biomolecules-13-01298-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/303d63790560/biomolecules-13-01298-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/844901faf686/biomolecules-13-01298-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/340bd38981e0/biomolecules-13-01298-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/26bc46bf5e00/biomolecules-13-01298-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/093d02739d9a/biomolecules-13-01298-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/0f77655f35d4/biomolecules-13-01298-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/2fbd1a9f8ac8/biomolecules-13-01298-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/2eb738b0d6c4/biomolecules-13-01298-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/3c5f2cfdef28/biomolecules-13-01298-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/43e5c0f86f5f/biomolecules-13-01298-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/df596dba8d23/biomolecules-13-01298-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/06a33efec723/biomolecules-13-01298-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/303d63790560/biomolecules-13-01298-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fad/10527026/844901faf686/biomolecules-13-01298-g012.jpg

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1
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2
Harnessing cytokines and chemokines for cancer therapy.利用细胞因子和趋化因子进行癌症治疗。
Nat Rev Clin Oncol. 2022 Apr;19(4):237-253. doi: 10.1038/s41571-021-00588-9. Epub 2022 Jan 7.
3
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data.clusterProfiler 4.0：用于解释组学数据的通用富集工具。
Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis.
揭示TRIM蛋白在胶质瘤发病机制中的多方面功能。
Transl Oncol. 2025 Aug;58:102419. doi: 10.1016/j.tranon.2025.102419. Epub 2025 May 26.
4
STAT3-mediated upregulation of TRIM6 promotes hepatocellular carcinoma invasion through the DDX58-Snail1 axis.STAT3介导的TRIM6上调通过DDX58-Snail1轴促进肝细胞癌侵袭。
Sci Rep. 2025 May 10;15(1):16284. doi: 10.1038/s41598-025-96548-9.
5
Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes.胎盘共转录激活因子类原基蛋白1（VGLL1）通过增加增殖和侵袭基因的转录来驱动肿瘤发生。
Front Oncol. 2024 Jun 7;14:1403052. doi: 10.3389/fonc.2024.1403052. eCollection 2024.
Innovation (Camb). 2021 Jul 1;2(3):100141. doi: 10.1016/j.xinn.2021.100141. eCollection 2021 Aug 28.
4
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5
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6
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