Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Int J Cancer. 2022 Jul 15;151(2):222-228. doi: 10.1002/ijc.33987. Epub 2022 Mar 7.
Glioma is an aggressive neoplasm of the brain with poorly understood etiology. A limited number of pathogens have been examined as glioma risk factors, but data from prospective studies with infection status determined before disease are lacking. Herpesviruses comprise a large family of DNA viruses that infect humans and are linked to a range of chronic diseases. We conducted a prospective evaluation of the association between antibody to six human herpesviruses and glioma risk in the Janus Serum Bank (Janus) and the Cancer Prevention Study-II (CPS-II). In Janus and CPS-II, the risk for glioma was not related to seroprevalence of herpes simplex virus-1, varicella zoster virus, or human herpes viruses 6A or 6B. In Janus, seropositivity to either the Epstein Barr virus (EBV) EA[D] or VCAp18 antigen was associated with a lower risk of glioma (ORs: 0.55 [95% CI 0.32-0.94] and 0.57 [95% CI 0.38-0.85]). This inverse association was consistent by histologic subtype and was observed for gliomas diagnosed up to two decades following antibody measurement. In Janus, seropositivity to at least one of three examined cytomegalovirus (CMV) antigens (pp150, pp52, pp28) was associated with an increased risk of nonglioblastoma (OR: 2.08 [95% CI 1.07-4.03]). This association was limited to tumors diagnosed within 12 years of antibody measurement. In summary, we report evidence of an inverse association between exposure to EBV and glioma. We further report that CMV exposure may be related to a higher likelihood of the nonglioblastoma subtype.
神经胶质瘤是一种侵袭性脑肿瘤，其病因尚不清楚。已经研究了少数病原体作为神经胶质瘤的危险因素，但缺乏在疾病发生之前确定感染状态的前瞻性研究数据。疱疹病毒是一组感染人类的 DNA 病毒，与一系列慢性疾病有关。我们在 Janus 血清库（Janus）和癌症预防研究-II（CPS-II）中对六种人类疱疹病毒抗体与神经胶质瘤风险之间的关联进行了前瞻性评估。在 Janus 和 CPS-II 中，疱疹病毒血清阳性与单纯疱疹病毒 1、水痘带状疱疹病毒或人类疱疹病毒 6A 或 6B 的血清流行率无关。在 Janus 中，针对 Epstein Barr 病毒（EBV）EA[D]或 VCAp18 抗原的血清阳性与较低的神经胶质瘤风险相关（OR：0.55 [95%CI 0.32-0.94] 和 0.57 [95%CI 0.38-0.85]）。这种负相关在组织学亚型上是一致的，并且在抗体测量后长达二十年诊断出的神经胶质瘤中观察到。在 Janus 中，至少对三种检查的巨细胞病毒（CMV）抗原（pp150、pp52、pp28）中的一种呈血清阳性与非神经胶质瘤（OR：2.08 [95%CI 1.07-4.03]）的风险增加有关。这种关联仅限于在抗体测量后 12 年内诊断出的肿瘤。总之，我们报告了接触 EBV 与神经胶质瘤之间存在负相关的证据。我们进一步报告，CMV 暴露可能与非神经胶质瘤亚型的可能性增加有关。
