Department of Medicine, Marshall University School of Medicine, Marshall University, Huntington, WV 25701, USA.
Marshall Institute for Interdisciplinary Research, Marshall University School of Medicine, Huntington, WV 25703, USA.
Biomolecules. 2023 Sep 9;13(9):1369. doi: 10.3390/biom13091369.
Metabolic dysfunction-associated steatohepatitis (MASH) is one of the major risk factors for chronic liver disease and hepatocellular carcinoma (HCC). The incidence of MASH in Western countries continues to rise, driving HCC as the third cause of cancer-related death worldwide. HCC has become a major global health challenge, partly from the obesity epidemic promoting metabolic cellular disturbances but also from the paucity of biomarkers for its early detection. Over 50% of HCC cases are clinically present at a late stage, where curative measures are no longer beneficial. Currently, there is a paucity of both specific and sensitive biological markers for the early-stage detection of HCC. The search for biological markers in the diagnosis of early HCC in high-risk populations is intense. We described the potential role of surrogates for a liver biopsy in the screening and monitoring of patients at risk for nesting HCC.
代谢相关脂肪性肝炎（MASH）是慢性肝病和肝细胞癌（HCC）的主要危险因素之一。西方国家 MASH 的发病率持续上升，导致 HCC 成为全球癌症相关死亡的第三大原因。HCC 已成为一个主要的全球健康挑战，部分原因是肥胖症的流行导致代谢细胞紊乱，但也因为缺乏早期检测的生物标志物。超过 50%的 HCC 病例在临床上处于晚期，此时治疗措施已无济于事。目前，用于 HCC 早期检测的特异性和敏感性生物标志物都很缺乏。在高危人群中，人们正在积极寻找用于 HCC 早期诊断的生物标志物。我们描述了肝活检替代物在巢式 HCC 风险患者筛查和监测中的潜在作用。
