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Nat Aging. 2021 Oct;1(10):932-947. doi: 10.1038/s43587-021-00122-7. Epub 2021 Oct 11.
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10
In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction.在成年海马体中，慢性神经生长因子剥夺会将 GABA 能信号从超极化方向转向去极化方向。
J Neurosci. 2010 Jan 20;30(3):885-93. doi: 10.1523/JNEUROSCI.3326-09.2010.

γ-氨基丁酸信号传导：神经退行性疾病和神经发育障碍的治疗靶点

GABA Signaling: Therapeutic Targets for Neurodegenerative and Neurodevelopmental Disorders.

作者信息

Cherubini Enrico, Ben-Ari Yehezkel

机构信息

European Brain Research Institute (EBRI), Rita Levi-Montalcini Foundation, Viale Regina Elena 293-295, 00161 Roma, Italy.

Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, CEDEX 09, 13288 Marseille, France.

出版信息

Brain Sci. 2023 Aug 25;13(9):1240. doi: 10.3390/brainsci13091240.

DOI:10.3390/brainsci13091240
PMID:37759841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10526277/
Abstract

This Special Issue, "GABA Signaling: Therapeutic Targets for Neurodegenerative and Neurodevelopmental Disorders", focuses on a fundamental property of the neurotransmitter γ-aminobutyric acid (GABA), namely its capacity to shift, in particular conditions, from the hyperpolarizing to the depolarizing direction [...].

摘要

本期特刊“γ-氨基丁酸（GABA）信号传导：神经退行性疾病和神经发育障碍的治疗靶点”聚焦于神经递质γ-氨基丁酸（GABA）的一个基本特性，即在特定条件下，其作用方向从超极化转变为去极化的能力[……]