Wan Xiaoping, Wang Yong, Zhang Ye, Song Weiqun
Department of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, No. 45 Chang Chun Street, Beijing 100053, China.
Zhuhai UM Science & Technology Research Institute, No. 1889 Huandao East Road, Zhuhai 519031, China.
Brain Sci. 2023 Sep 8;13(9):1295. doi: 10.3390/brainsci13091295.
Frontal transcranial direct current stimulation (tDCS) and parietal tDCS are effective for treating disorders of consciousness (DoC); however, the relative efficacies of these techniques have yet to be determined. This paper compares the neuromodulation effects of frontal and parietal tDCS on DoC. Twenty patients with DoC were recruited and randomly assigned to two groups. One group received single-session frontal tDCS and single-session sham tDCS. The other group received single-session parietal tDCS and single-session sham tDCS. Before and after every tDCS session, we recorded coma recovery scale-revised (CRS-R) values and an electroencephalogram. CRS-R was also used to evaluate the state of consciousness at 9-12-month follow-up. Both single-session frontal and parietal tDCS caused significant changes in the genuine permutation cross-mutual information (G_PCMI) of local frontal and across brain regions ( < 0.05). Furthermore, the changes in G_PCMI values were significantly correlated to the CRS-R scores at 9-12-month follow-up after frontal and parietal tDCS ( < 0.05). The changes in G_PCMI and CRS-R scores were also correlated ( < 0.05). Both frontal tDCS and parietal tDCS exert neuromodulatory effects in DoC and induce significant changes in electrophysiology. G_PCMI can be used to evaluate the neuromodulation effects of tDCS.
额叶经颅直流电刺激（tDCS）和顶叶tDCS对意识障碍（DoC）的治疗有效；然而，这些技术的相对疗效尚未确定。本文比较了额叶和顶叶tDCS对DoC的神经调节作用。招募了20名DoC患者并随机分为两组。一组接受单次额叶tDCS和单次假tDCS。另一组接受单次顶叶tDCS和单次假tDCS。在每次tDCS治疗前后，我们记录了昏迷恢复量表修订版（CRS-R）值和脑电图。CRS-R也用于评估9至12个月随访时的意识状态。单次额叶和顶叶tDCS均导致额叶局部和全脑区域的真实排列交叉互信息（G_PCMI）发生显著变化（<0.05）。此外，额叶和顶叶tDCS后9至12个月随访时，G_PCMI值的变化与CRS-R评分显著相关（<0.05）。G_PCMI和CRS-R评分的变化也具有相关性（<0.05）。额叶tDCS和顶叶tDCS均对DoC发挥神经调节作用并诱导电生理发生显著变化。G_PCMI可用于评估tDCS的神经调节作用。
