Jiménez-Jiménez F J, Fernández-Calle P, Martínez-Vanaclocha M, Herrero E, Molina J A, Vázquez A, Codoceo R
Department of Neurology, Hospital Universitario San Carlos, Madrid, Spain.
J Neurol Sci. 1992 Oct;112(1-2):30-3. doi: 10.1016/0022-510x(92)90127-7.
Several recent studies have shown decreased copper and increased zinc concentrations in the substantia nigra and increased copper concentrations in the cerebrospinal fluid of Parkinson's disease patients. To elucidate whether changes in serum levels of these trace elements may increase the risk of developing Parkinson's disease (PD), we assessed serum levels of zinc and copper by flame atomic absorption spectrophotometry, and albumin and ceruloplasmin, in 32 (Zn) and 39 PD patients (Cu), respectively, with their spouses as the control group. Serum zinc, albumin, copper and ceruloplasmin levels and the zinc/albumin and copper/ceruloplasmin ratios, did not differ significantly between the two groups and were not influenced by antiparkinsonian therapy in the PD patients. Serum zinc/albumin ratio (r = 0.43), ceruloplasmin (r = -0.36) and copper/ceruloplasmin ratio (r = 0.36) correlated significantly with age, but not with age of onset, duration of the disease, scores of the Unified Parkinson's Disease Rating Scale and Hoehn and Yahr staging in PD patients. These values did not correlate with age in the control group. These results suggest that serum levels of zinc and copper do not play any role as risk factors for PD.
最近的几项研究表明，帕金森病患者黑质中的铜含量降低、锌含量升高，且脑脊液中的铜含量升高。为了阐明这些微量元素血清水平的变化是否会增加患帕金森病（PD）的风险，我们分别通过火焰原子吸收分光光度法评估了32例（锌研究）和39例帕金森病患者（铜研究）的血清锌、铜水平，以及白蛋白和铜蓝蛋白水平，并以他们的配偶作为对照组。两组之间的血清锌、白蛋白、铜和铜蓝蛋白水平以及锌/白蛋白和铜/铜蓝蛋白比值没有显著差异，且帕金森病患者的抗帕金森治疗对这些指标没有影响。血清锌/白蛋白比值（r = 0.43）、铜蓝蛋白（r = -0.36）和铜/铜蓝蛋白比值（r = 0.36）与年龄显著相关，但与帕金森病患者的发病年龄、病程、统一帕金森病评定量表评分以及Hoehn和Yahr分期无关。在对照组中，这些值与年龄无关。这些结果表明，血清锌和铜水平作为帕金森病的危险因素没有任何作用。
