Boll M C, Sotelo J, Otero E, Alcaraz-Zubeldia M, Rios C
Department of Neurology, National Institute of Neurology and Neurosurgery Manuel Velsasco Suarez, Mexico, Mexico.
Neurosci Lett. 1999 Apr 23;265(3):155-8. doi: 10.1016/s0304-3940(99)00221-9.
Recent evidence suggest the implication of transition metals leading to overproduction of free radicals as a possible causal factor in the death of nigral cells associated to Parkinson's disease (PD). Iron depots in the basal ganglia of PD patients have been described; in addition, contents of nigral copper have been found decreased, while its concentration in cerebrospinal fluid (CSF) is raised, particularly the free form of the metal. To search for a possible link between altered copper concentrations and PD, we advanced the hypothesis that ferroxidase activity of ceruloplasmin is decreased in the CSF of PD patients. We studied 35 untreated PD patients, 14 L-3,4-dihydroxyphenylalanine (L-DOPA)-treated PD patients and 26 controls. Both CSF ferroxidase activity and CSF copper content were measured and correlated with the clinical stage of the disease. We found that untreated PD patients had a significant reduction of 40% in CSF ferroxidase while CSF copper was slightly increased as compared with both the values in L-DOPA-treated PD patients and controls. We also found that the fraction of copper linked to ferroxidase in untreated PD is inversely related to the clinical stage of the disease.
最近的证据表明，过渡金属导致自由基过度产生，这可能是帕金森病（PD）相关黑质细胞死亡的一个致病因素。已描述了PD患者基底神经节中的铁储存；此外，还发现黑质铜含量降低，而其在脑脊液（CSF）中的浓度升高，尤其是金属的游离形式。为了寻找铜浓度改变与PD之间的可能联系，我们提出了一个假设，即PD患者脑脊液中铜蓝蛋白的铁氧化酶活性降低。我们研究了35例未经治疗的PD患者、14例接受L-3,4-二羟基苯丙氨酸（L-DOPA）治疗的PD患者和26名对照。测量了脑脊液铁氧化酶活性和脑脊液铜含量，并将其与疾病的临床分期相关联。我们发现，与接受L-DOPA治疗的PD患者和对照相比，未经治疗的PD患者脑脊液铁氧化酶显著降低40%，而脑脊液铜略有增加。我们还发现，未经治疗的PD中与铁氧化酶结合的铜部分与疾病的临床分期呈负相关。
