Simón Layla, Arazo-Rusindo Migdalia, Quest Andrew F G, Mariotti-Celis María Salomé
Nutrition and Dietetic School, Facultad de Medicina, Universidad Finis Terrae, Santiago 7501015, Chile.
Cellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Program of Cell and Molecular Biology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8380000, Chile.
Antioxidants (Basel). 2023 Sep 7;12(9):1734. doi: 10.3390/antiox12091734.
Mitochondrial dysfunction is an interesting therapeutic target to help reduce cancer deaths, and the use of bioactive compounds has emerged as a novel and safe approach to solve this problem. Here, we discuss the information available related to phlorotannins, a type of polyphenol present in brown seaweeds that reportedly functions as antioxidants/pro-oxidants and anti-inflammatory and anti-tumorigenic agents. Specifically, available evidence indicates that dieckol and phloroglucinol promote mitochondrial membrane depolarization and mitochondria-dependent apoptosis. Phlorotannins also reduce pro-tumorigenic, -inflammatory, and -angiogenic signaling mechanisms involving RAS/MAPK/ERK, PI3K/Akt/mTOR, NF-κB, and VEGF. In doing so, they inhibit pathways that favor cancer development and progression. Unfortunately, these compounds are rather labile and, therefore, this review also summarizes approaches permitting the encapsulation of bioactive compounds, like phlorotannins, and their subsequent oral administration as novel and non-invasive therapeutic alternatives for cancer treatment.
线粒体功能障碍是一个有助于降低癌症死亡率的有趣治疗靶点，使用生物活性化合物已成为解决这一问题的一种新颖且安全的方法。在此，我们讨论与褐藻多酚相关的现有信息，褐藻多酚是一种存在于褐藻中的多酚类物质，据报道其具有抗氧化/促氧化剂以及抗炎和抗肿瘤作用。具体而言，现有证据表明，二eckol和间苯三酚可促进线粒体膜去极化和线粒体依赖性凋亡。褐藻多酚还可减少涉及RAS/MAPK/ERK、PI3K/Akt/mTOR、NF-κB和VEGF的促肿瘤、促炎和促血管生成信号机制。通过这样做，它们抑制了有利于癌症发展和进展的途径。不幸的是，这些化合物相当不稳定，因此，本综述还总结了允许封装生物活性化合物（如褐藻多酚）并随后口服给药作为癌症治疗的新型非侵入性治疗选择的方法。
