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通过TLR/TGF-β途径抑制BALB/c小鼠暴露于慢性颗粒物后的肺功能障碍

Suppressed Chronic PM-Exposed Pulmonary Dysfunction via TLR/TGF-β Pathway in BALB/c Mice.

作者信息

Kim Tae Yoon, Kim Jong Min, Lee Hyo Lim, Go Min Ji, Joo Seung Gyum, Kim Ju Hui, Lee Han Su, Jeong Won Min, Lee Dong Yeol, Kim Hyun-Jin, Heo Ho Jin

机构信息

Division of Applied Life Science (BK21), Institute of Agriculture and Life Science, Gyeonsang National University, Jinju 52828, Republic of Korea.

Research & Development Team, Gyeongnam Anti-Aging Research Institute, Sancheong 52215, Republic of Korea.

出版信息

Antioxidants (Basel). 2023 Sep 10;12(9):1743. doi: 10.3390/antiox12091743.

DOI:10.3390/antiox12091743
PMID:37760047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10525573/
Abstract

This study investigated the ameliorating effect of the aqueous extract of on PM-induced pulmonary dysfunction. The major compounds of were identified as palmitic acid, stearic acid, and oleamide using GC/MS and hexadecanamide, oleamide, and 13-docosenamide using UPLC-Q-TOF/MS. improved pulmonary antioxidant system deficit by regulating SOD activities and reducing GSH levels and MDA contents. It suppressed pulmonary mitochondrial dysfunction by regulating ROS contents and mitochondrial membrane potential levels. It regulated the inflammatory protein levels of TLR4, MyD88, p-JNK, p-NF-κB, iNOS, Caspase-1, TNF-α, and IL-1β. In addition, it improved the apoptotic protein expression of BCl-2, BAX, and Caspase-3 and attenuated the fibrous protein expression of TGF-β1, p-Smad-2, p-Smad-3, MMP-1, and MMP-2. In conclusion, this study suggests that might be a potential material for functional food or pharmaceuticals to improve lung damage by regulating oxidative stress inflammation, cytotoxicity, and fibrosis via the TLR/TGF-β1 signaling pathway.

摘要

本研究调查了[提取物名称]水提取物对颗粒物诱导的肺功能障碍的改善作用。使用气相色谱/质谱联用仪（GC/MS）将[提取物名称]的主要化合物鉴定为棕榈酸、硬脂酸和油酰胺，使用超高效液相色谱-四极杆-飞行时间质谱仪（UPLC-Q-TOF/MS）鉴定为十六酰胺、油酰胺和13-二十二碳酰胺。[提取物名称]通过调节超氧化物歧化酶（SOD）活性、降低谷胱甘肽（GSH）水平和丙二醛（MDA）含量，改善了肺抗氧化系统缺陷。它通过调节活性氧（ROS）含量和线粒体膜电位水平，抑制了肺线粒体功能障碍。它调节了Toll样受体4（TLR4）、髓样分化因子88（MyD88）、磷酸化c-Jun氨基末端激酶（p-JNK）、磷酸化核因子κB（p-NF-κB）、诱导型一氧化氮合酶（iNOS）、半胱天冬酶-1（Caspase-1）、肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）的炎症蛋白水平。此外，它改善了B细胞淋巴瘤-2（BCl-2）、Bcl-2相关X蛋白（BAX）和半胱天冬酶-3（Caspase-3）的凋亡蛋白表达，并减弱了转化生长因子-β1（TGF-β1）、磷酸化Smad2（p-Smad-2）、磷酸化Smad3（p-Smad-3）、基质金属蛋白酶-1（MMP-1）和基质金属蛋白酶-2（MMP-2）的纤维蛋白表达。总之，本研究表明，[提取物名称]可能是一种潜在的功能性食品或药物原料，可通过TLR/TGF-β1信号通路调节氧化应激、炎症、细胞毒性和纤维化，从而改善肺损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/4dc4941b85a7/antioxidants-12-01743-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/af9854bae428/antioxidants-12-01743-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/de116eca8332/antioxidants-12-01743-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/9e1cce464873/antioxidants-12-01743-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/d0709657acfb/antioxidants-12-01743-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/66bf3bbdc4fa/antioxidants-12-01743-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/a33ac8d5f2a0/antioxidants-12-01743-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/4dc4941b85a7/antioxidants-12-01743-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/af9854bae428/antioxidants-12-01743-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/2ee5e9914e85/antioxidants-12-01743-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/de116eca8332/antioxidants-12-01743-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/9e1cce464873/antioxidants-12-01743-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/d0709657acfb/antioxidants-12-01743-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/66bf3bbdc4fa/antioxidants-12-01743-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/a33ac8d5f2a0/antioxidants-12-01743-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8917/10525573/4dc4941b85a7/antioxidants-12-01743-g008.jpg

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