• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种源自[具体来源1]和[具体来源2]的联合提取物通过NF-κB/TGF-β1通路减轻PM诱导的呼吸道损伤。

A Combined Extract from and Mitigates PM-Induced Respiratory Damage by NF-κB/TGF-β1 Pathway.

作者信息

Kim In Young, Lee Hyo Lim, Choi Hye Ji, Ju Yeong Hyeon, Heo Yu Mi, Na Hwa Rang, Lee Dong Yeol, Jeong Won Min, Heo Ho Jin

机构信息

Division of Applied Life Science (BK21), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea.

Research & Development Team, Gyeongnam Anti-Aging Research Institute, Sancheong 52215, Republic of Korea.

出版信息

Antioxidants (Basel). 2024 Dec 20;13(12):1572. doi: 10.3390/antiox13121572.

DOI:10.3390/antiox13121572
PMID:39765899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11673267/
Abstract

This research evaluated the protective role of a combined extract of and (DBZO) against respiratory dysfunction caused by particulate matter (PM) exposure in BALB/c mice. The bioactive compounds identified in the DBZO are catechin, astragalin, 6-gingerol, 8-gingerol, and 6-shogaol. DBZO ameliorated cell viability and reactive oxygen species (ROS) production in PM-stimulated A549 and RPMI 2650 cells. In addition, it significantly alleviated respiratory dysfunction in BALB/c mice exposed to PM. DBZO improved the antioxidant systems in lung tissues by modulating malondialdehyde (MDA) content, as well as levels of reduced glutathione (GSH) and superoxide dismutase (SOD). Likewise, DBZO restored mitochondrial dysfunction by improving ROS levels, mitochondrial membrane potential, and ATP production. Moreover, DBZO modulated the levels of neutrophils, eosinophils, monocytes, and lymphocytes (specifically CD4, CD8, and CD4IL-4 T cells) in blood and IgE levels in serum. DBZO was shown to regulate the c-Jun N-terminal kinase (JNK) pathway, nuclear factor kappa B (NF-κB) pathway, and transforming growth factor β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) pathway. Histopathological observation indicated that DBZO mitigates the increase in alveolar septal thickness. These findings indicate that DBZO is a promising natural agent for improving respiratory health.

摘要

本研究评估了 和 （DBZO）的联合提取物对BALB/c小鼠暴露于颗粒物（PM）所引起的呼吸功能障碍的保护作用。在DBZO中鉴定出的生物活性化合物有儿茶素、黄芪苷、6-姜酚、8-姜酚和6-姜烯酚。DBZO改善了PM刺激的A549和RPMI 2650细胞的细胞活力和活性氧（ROS）生成。此外，它显著减轻了暴露于PM的BALB/c小鼠的呼吸功能障碍。DBZO通过调节丙二醛（MDA）含量以及还原型谷胱甘肽（GSH）和超氧化物歧化酶（SOD）水平，改善了肺组织中的抗氧化系统。同样，DBZO通过改善ROS水平、线粒体膜电位和ATP生成，恢复了线粒体功能障碍。此外，DBZO调节了血液中中性粒细胞、嗜酸性粒细胞、单核细胞和淋巴细胞（特别是CD4、CD8和CD4IL-4 T细胞）的水平以及血清中IgE水平。DBZO被证明可调节c-Jun氨基末端激酶（JNK）途径、核因子κB（NF-κB）途径和转化生长因子β（TGF-β）/抗五聚体母系抑制因子（Smad）途径。组织病理学观察表明，DBZO减轻了肺泡间隔厚度的增加。这些发现表明，DBZO是一种有望改善呼吸健康的天然药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/e61c2782c775/antioxidants-13-01572-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/75e58ae16262/antioxidants-13-01572-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/d2eda726f584/antioxidants-13-01572-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/49f5b065bf69/antioxidants-13-01572-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/d9474a97ac7b/antioxidants-13-01572-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/15c74206cdba/antioxidants-13-01572-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/e7d922facc4e/antioxidants-13-01572-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/51332947c460/antioxidants-13-01572-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/d805e968a1db/antioxidants-13-01572-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/e61c2782c775/antioxidants-13-01572-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/75e58ae16262/antioxidants-13-01572-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/d2eda726f584/antioxidants-13-01572-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/49f5b065bf69/antioxidants-13-01572-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/d9474a97ac7b/antioxidants-13-01572-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/15c74206cdba/antioxidants-13-01572-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/e7d922facc4e/antioxidants-13-01572-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/51332947c460/antioxidants-13-01572-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/d805e968a1db/antioxidants-13-01572-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16e4/11673267/e61c2782c775/antioxidants-13-01572-g009.jpg

相似文献

1
A Combined Extract from and Mitigates PM-Induced Respiratory Damage by NF-κB/TGF-β1 Pathway.一种源自[具体来源1]和[具体来源2]的联合提取物通过NF-κB/TGF-β1通路减轻PM诱导的呼吸道损伤。
Antioxidants (Basel). 2024 Dec 20;13(12):1572. doi: 10.3390/antiox13121572.
2
Protective Effect of on PM-Induced Pulmonary Damage in BALB/c Mice via the TGF-β and NF-κB Pathway.通过TGF-β和NF-κB途径对PM诱导的BALB/c小鼠肺损伤的保护作用
Antioxidants (Basel). 2023 Apr 20;12(4):968. doi: 10.3390/antiox12040968.
3
Phytosome-Encapsulated 6-Gingerol- and 6-Shogaol-Enriched Extracts from Roscoe Protect Against Oxidative Stress-Induced Neurotoxicity.从山奈中提取的植物脂质体包裹的富含6-姜酚和6-姜烯酚的提取物可预防氧化应激诱导的神经毒性。
Molecules. 2024 Dec 22;29(24):6046. doi: 10.3390/molecules29246046.
4
Mercury chloride causes cognitive impairment, oxidative stress and neuroinflammation in male Wistar rats: The potential protective effect of 6-gingerol-rich fraction of Zingiber officinale via regulation of antioxidant defence system and reversal of pro-inflammatory markers increase.氯化汞可导致雄性Wistar大鼠认知功能障碍、氧化应激和神经炎症：姜中富含6-姜酚的提取物通过调节抗氧化防御系统和逆转促炎标志物增加发挥潜在保护作用。
Brain Res. 2024 Mar 1;1826:148741. doi: 10.1016/j.brainres.2023.148741. Epub 2023 Dec 27.
5
Euglena gracilis-derived β-glucan ameliorates particulate matter (PM)-induced airway inflammation by modulating nuclear factor kappa B, mitogen-activated protein kinase, and nuclear factor erythroid 2-related factor 2 signaling pathways in A549 cells and BALB/c mice.纤细裸藻衍生的β-葡聚糖通过调节A549细胞和BALB/c小鼠中的核因子κB、丝裂原活化蛋白激酶和核因子红细胞2相关因子2信号通路，改善颗粒物（PM）诱导的气道炎症。
Int J Biol Macromol. 2025 Mar;296:139671. doi: 10.1016/j.ijbiomac.2025.139671. Epub 2025 Jan 9.
6
Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.姜（Zingiber officinale Roscoe）提取物及其主要活性成分 6-姜酚通过激活 AMPK-PGC1α 信号通路促进线粒体生物发生。
J Food Sci. 2019 Aug;84(8):2101-2111. doi: 10.1111/1750-3841.14723. Epub 2019 Aug 1.
7
A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.党参根多糖通过调节 TLR4/NF-κB 和 TGF-β1/Smad3 信号通路减轻四氯化碳诱导的肝纤维化。
Int Immunopharmacol. 2023 Jun;119:110180. doi: 10.1016/j.intimp.2023.110180. Epub 2023 Apr 15.
8
Reactive oxygen species/c-Jun N-terminal kinase/nuclear factor kappa-B signaling molecules are involved in pe-riodontitis-induced liver injury by regulating apoptosis.活性氧/c-Jun氨基末端激酶/核因子κB信号分子通过调节细胞凋亡参与牙周炎诱导的肝损伤。
Hua Xi Kou Qiang Yi Xue Za Zhi. 2022 Oct 1;40(5):532-540. doi: 10.7518/hxkq.2022.05.005.
9
Suppressed Chronic PM-Exposed Pulmonary Dysfunction via TLR/TGF-β Pathway in BALB/c Mice.通过TLR/TGF-β途径抑制BALB/c小鼠暴露于慢性颗粒物后的肺功能障碍
Antioxidants (Basel). 2023 Sep 10;12(9):1743. doi: 10.3390/antiox12091743.
10
Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach.生姜及6-姜酚减轻氯化汞诱导的雄性大鼠肝肾损伤及氧化应激：一种保护方法。
Biomed Pharmacother. 2017 Jul;91:645-655. doi: 10.1016/j.biopha.2017.04.108. Epub 2017 May 8.

本文引用的文献

1
Particulate Matter-Induced Emerging Health Effects Associated with Oxidative Stress and Inflammation.与氧化应激和炎症相关的颗粒物诱导的新出现的健康影响。
Antioxidants (Basel). 2024 Oct 17;13(10):1256. doi: 10.3390/antiox13101256.
2
Biological network comparison identifies a novel synergistic mechanism of Ginseng Radix-Astragali Radix herb pair in cancer-related fatigue.生物网络比较揭示人参-黄芪药对治疗癌症相关性疲劳的新协同机制。
J Ethnopharmacol. 2024 Oct 28;333:118447. doi: 10.1016/j.jep.2024.118447. Epub 2024 Jun 15.
3
Advances in nano-based drug delivery systems for the management of cytokine influx-mediated inflammation in lung diseases.
用于治疗肺部疾病中细胞因子流入介导的炎症的纳米药物递送系统的进展。
Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun;397(6):3695-3707. doi: 10.1007/s00210-023-02882-y. Epub 2023 Dec 11.
4
Antioxidant therapy against TGF-β/SMAD pathway involved in organ fibrosis.抗氧化治疗对抗 TGF-β/SMAD 通路在器官纤维化中的作用。
J Cell Mol Med. 2024 Jan;28(2):e18052. doi: 10.1111/jcmm.18052. Epub 2023 Dec 2.
5
From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration.从失衡到损伤：活性氧在氧化应激诱导的疾病中的核心作用及治疗探索
Front Pharmacol. 2023 Oct 18;14:1269581. doi: 10.3389/fphar.2023.1269581. eCollection 2023.
6
Astragalin: a food-origin flavonoid with therapeutic effect for multiple diseases.黄芪苷：一种具有多种疾病治疗作用的食物源黄酮类化合物。
Front Pharmacol. 2023 Oct 18;14:1265960. doi: 10.3389/fphar.2023.1265960. eCollection 2023.
7
Suppressed Chronic PM-Exposed Pulmonary Dysfunction via TLR/TGF-β Pathway in BALB/c Mice.通过TLR/TGF-β途径抑制BALB/c小鼠暴露于慢性颗粒物后的肺功能障碍
Antioxidants (Basel). 2023 Sep 10;12(9):1743. doi: 10.3390/antiox12091743.
8
Protective Effect of on PM-Induced Pulmonary Damage in BALB/c Mice via the TGF-β and NF-κB Pathway.通过TGF-β和NF-κB途径对PM诱导的BALB/c小鼠肺损伤的保护作用
Antioxidants (Basel). 2023 Apr 20;12(4):968. doi: 10.3390/antiox12040968.
9
Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries.急性和慢性肺损伤中的氧化应激与炎症
Antioxidants (Basel). 2023 Feb 21;12(3):548. doi: 10.3390/antiox12030548.
10
Particulate matter and ultrafine particles in urban air pollution and their effect on the nervous system.城市空气污染中的颗粒物和超细颗粒物及其对神经系统的影响。
Environ Sci Process Impacts. 2023 Apr 26;25(4):704-726. doi: 10.1039/d2em00276k.