Pinho Stella Catunda, Heinke Thais, Dutra Paula Fernanda Santos Pallone, Carmo Andreia, Salmeron Camilla, Karoleski Luciana, Focchi Gustavo, Speck Neila Maria Góis, Pennati Beatrice Marina, Silva Ivaldo
Department of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.
Clinical Research and Practice Department, El.En. Group, 50041 Calenzano, Italy.
Bioengineering (Basel). 2023 Sep 15;10(9):1087. doi: 10.3390/bioengineering10091087.
To compare the efficacy of CO fractional laser with that of topical estriol for treating genitourinary syndrome of menopause and to investigate the relationship between epithelial thickness and vaginal atrophy.
Twenty-five menopausal women were randomized to receive either laser or estrogen treatment. Vaginal biopsies before and after treatment were compared to assess the amount and distribution of estrogen and progesterone receptors.
Estrogen receptor levels were statistically similar between groups before and after treatment. Although there was no change over time in the estrogen group, an increase in receptor levels was confirmed in the laser group. Changes in estrogen receptor levels showed no association with treatment. Progesterone receptor levels were statistically similar between groups throughout treatment. There was no change over time in both groups. These changes displayed no association with the type of treatment. There was no significant correlation between epithelium thickness and estrogen or progesterone receptor levels.
Estrogen and progesterone receptor levels increased and were maintained, respectively, in the vaginal epithelium in both groups. There was no significant relationship between epithelium thickness and receptor density. Laser therapy had similar outcomes to the gold standard without involving the disadvantages of hormone therapy.
比较二氧化碳分次激光与局部使用雌三醇治疗绝经后泌尿生殖综合征的疗效，并探讨上皮厚度与阴道萎缩之间的关系。
25名绝经后女性被随机分为接受激光治疗或雌激素治疗两组。比较治疗前后的阴道活检结果，以评估雌激素和孕激素受体的数量及分布。
治疗前后两组间雌激素受体水平在统计学上相似。虽然雌激素组随时间无变化，但激光组受体水平得到证实有所增加。雌激素受体水平的变化与治疗无关。整个治疗过程中两组间孕激素受体水平在统计学上相似。两组随时间均无变化。这些变化与治疗类型无关。上皮厚度与雌激素或孕激素受体水平之间无显著相关性。
两组阴道上皮中雌激素和孕激素受体水平分别升高并得以维持。上皮厚度与受体密度之间无显著关系。激光治疗与金标准治疗效果相似，且无激素治疗的缺点。
