Fomichenko K V, Ermakov V F
Vopr Med Khim. 1986 Sep-Oct;32(5):21-4.
Essentiale or vitohepatum were administered into 26-28 months old Wistar rats to stabilize the lysosomal membranes. Administration of essentiale (cyancobalamine standardization at a dose of 0.286 microgram/kg) within 21 days led to a decrease in total activity of acid DNAase, acid phosphatase, cathepsin D, hyaluronidase without distinct changes in acid RNAase activity. Vitohepatum administered similarly (cyancobalamine standardization at a dose of 0.27 microgram/kg) caused a decrease in total activity of lysosomal enzymes acid DNAase acid phosphatase, cathepsin D, did not affect hyaluronidase and acid RNAase activities. The administration of the both drugs was also accompanied by a decrease in non-sedimented activity of the enzymes studied.
将Essentiale或肝维隆（Vitohepatum）给予26 - 28月龄的Wistar大鼠，以稳定溶酶体膜。连续21天给予Essentiale（以0.286微克/千克的剂量进行氰钴胺标准化）导致酸性DNA酶、酸性磷酸酶、组织蛋白酶D、透明质酸酶的总活性降低，而酸性RNA酶活性无明显变化。以类似方式给予肝维隆（以0.27微克/千克的剂量进行氰钴胺标准化）导致溶酶体酶酸性DNA酶、酸性磷酸酶、组织蛋白酶D的总活性降低，对透明质酸酶和酸性RNA酶活性无影响。给予这两种药物还伴随着所研究酶的非沉淀活性降低。
