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[抗凝血酶III对凝血酶的中和作用取决于实验性及临床外科手术中凝血酶形成的强度]

[Thrombin neutralization by antithrombin III depending upon the intensity of thrombin-formation in experimental and clinical surgical interventions].

作者信息

Pastorova V E, Tabakina T E, Ivanov A Iu

出版信息

Vopr Med Khim. 1986 Sep-Oct;32(5):28-32.

PMID:3776113
Abstract

Low rate of thrombinogenesis, its gradual and prolonged development in animal circulation after small-scale surgical operations was accompanied by a compensatory increase in the activity of antithrombin III. After surgical operations of lung in children thrombinoformation at the high rate led to distinct short-term consumption and to decrease in activity of the inhibitor during the operation period and within 2-3 days after the operation simultaneously with activation of enzymatic and nonenzymatic fibrinolysis. At the same time, any postoperational thrombotic complications were not observed in the children.

摘要

凝血酶生成率低,在小型外科手术后动物循环中其发展缓慢且持续时间长,同时抗凝血酶III活性出现代偿性增加。儿童肺部手术后,凝血形成速度快导致明显的短期消耗,在手术期间以及术后2 - 3天内,抑制剂活性下降,同时酶促和非酶促纤维蛋白溶解被激活。与此同时,这些儿童未观察到任何术后血栓形成并发症。

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Vopr Med Khim. 1986 Sep-Oct;32(5):28-32.
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