Pastorova V E, Bazaz'ian G G, Liapina L A
Biull Eksp Biol Med. 1984 Nov;98(11):560-3.
Old rats aged 12-18 months and rats kept on an atherogenic diet for 3.5 months demonstrate high blood antithrombin III content at the initial period of the development of anticoagulation function suppression and of hypercoagulation. During long-developing hypercoagulation, the high content of antithrombin III might be regarded as compensatory reaction interfering with formation in the blood of thrombin microamounts. With hypercoagulation becoming more pronounced and with a further increase of blood thrombin concentration the content of antithrombin III progressively descends, which is accompanied by steady development of anticoagulation function suppression.
12至18个月的老龄大鼠以及食用致动脉粥样化饮食3.5个月的大鼠，在抗凝功能抑制和高凝状态发展的初期，血液中抗凝血酶III含量较高。在长期发展的高凝状态过程中，抗凝血酶III的高含量可能被视为一种补偿反应，干扰血液中微量凝血酶的形成。随着高凝状态变得更加明显以及血液凝血酶浓度进一步升高，抗凝血酶III的含量逐渐下降，同时伴随着抗凝功能抑制的持续发展。
