Vlasov B Ia, Khrustselevskaia A M
Vopr Med Khim. 1986 Sep-Oct;32(5):44-7.
Simulation of reparative osteogenesis in diaphysis fracture of rat femur showed that liver tissue citrate synthase was a key enzyme in metabolism of citrate under conditions of organic matrix development in regenerating tissue. The liver enzyme as well as the callus citrate synthase were responsible for high rate of lipogenesis (activation of ATP-citrate lyase) and for an increase in content of citric acid within the initial period of consolidation. At the late steps of reparation callus citrate synthase, involved in citrate metabolism, promoted activation of energy-dependent reactions of calcification (stimulation of NAD-isocitrate dehydrogenase) and determined the dynamics of the metabolite concentration.
大鼠股骨骨干骨折修复性骨生成的模拟显示，在再生组织有机基质发育的条件下，肝组织柠檬酸合酶是柠檬酸代谢的关键酶。该肝酶以及骨痂柠檬酸合酶负责在愈合初期的高脂肪生成率（激活ATP-柠檬酸裂解酶）以及柠檬酸含量的增加。在修复后期，参与柠檬酸代谢的骨痂柠檬酸合酶促进了能量依赖性钙化反应的激活（刺激NAD-异柠檬酸脱氢酶）并决定了代谢物浓度的动态变化。
