胃胰腺神经内分泌肿瘤的预后评估:影像组学的前景与局限

Prognostic Assessment of Gastropancreatic Neuroendocrine Neoplasm: Prospects and Limits of Radiomics.

作者信息

De Muzio Federica, Pellegrino Fabio, Fusco Roberta, Tafuto Salvatore, Scaglione Mariano, Ottaiano Alessandro, Petrillo Antonella, Izzo Francesco, Granata Vincenza

机构信息

Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.

Radiology Division, S. Bonifacio Hospital, 37047 Verona, Italy.

出版信息

Diagnostics (Basel). 2023 Sep 7;13(18):2877. doi: 10.3390/diagnostics13182877.

Abstract

Neuroendocrine neoplasms (NENs) are a group of lesions originating from cells of the diffuse neuroendocrine system. NENs may involve different sites, including the gastrointestinal tract (GEP-NENs). The incidence and prevalence of GEP-NENs has been constantly rising thanks to the increased diagnostic power of imaging and immuno-histochemistry. Despite the plethora of biochemical markers and imaging techniques, the prognosis and therapeutic choice in GEP-NENs still represents a challenge, mainly due to the great heterogeneity in terms of tumor lesions and clinical behavior. The concept that biomedical images contain information about tissue heterogeneity and pathological processes invisible to the human eye is now well established. From this substrate comes the idea of radiomics. Computational analysis has achieved promising results in several oncological settings, and the use of radiomics in different types of GEP-NENs is growing in the field of research, yet with conflicting results. The aim of this narrative review is to provide a comprehensive update on the role of radiomics on GEP-NEN management, focusing on the main clinical aspects analyzed by most existing reports: predicting tumor grade, distinguishing NET from other tumors, and prognosis assessment.

摘要

神经内分泌肿瘤(NENs)是一组起源于弥漫性神经内分泌系统细胞的病变。NENs可累及不同部位,包括胃肠道(GEP-NENs)。由于影像学和免疫组织化学诊断能力的提高,GEP-NENs的发病率和患病率一直在不断上升。尽管有大量的生化标志物和影像学技术,但GEP-NENs的预后和治疗选择仍然是一个挑战,主要是由于肿瘤病变和临床行为存在很大的异质性。生物医学图像包含肉眼看不见的组织异质性和病理过程信息这一概念现已得到充分确立。由此产生了放射组学的概念。计算分析在多种肿瘤学环境中取得了有前景的结果,放射组学在不同类型的GEP-NENs中的应用在研究领域不断增加,但结果相互矛盾。本叙述性综述的目的是全面更新放射组学在GEP-NEN管理中的作用,重点关注大多数现有报告分析的主要临床方面:预测肿瘤分级、将神经内分泌肿瘤与其他肿瘤区分开来以及预后评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/936c/10529975/5bdd53651fb2/diagnostics-13-02877-g001.jpg

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