Department of Biochemistry and General Chemistry, Medical College of The University of Rzeszów, Rzeszów University, 35-959 Rzeszów, Poland.
Students Biochemistry Science Club, Medical College of The University of Rzeszów, Rzeszów University, Kopisto 2a, 35-959 Rzeszów, Poland.
Molecules. 2022 Oct 13;27(20):6847. doi: 10.3390/molecules27206847.
The treatment of neoplastic disease of the brain is still a challenge for modern medicine. Therefore, advanced methodologies are needed that can rationally and successfully contribute to the early diagnosis of primary and metastatic tumors growing within the brain. Photodynamic therapy (PDT) seems to be a valuable method of treatment for precancerous and cancerous lesions including brain tumors. The main advantage of PDT is its high efficiency, minimal invasiveness and no serious side effects, compared with chemotherapy and radiotherapy. This review was conducted through a comprehensive search of articles, scientific information databases and the websites of organizations dealing with cancer treatment. Key points from clinical trials conducted by other researchers are also discussed. The common databases such as PubMed, Google Scholar, EBSCO, Scopus, and Elsevier were used. Articles in the English language of reliable credibility were mainly analyzed. The type of publications considered included clinical and preclinical studies, systematic reviews, and case reports. Based on these collected materials, we see that scientists have already demonstrated the potential of PDT application in the field of brain tumors. Therefore, in this review, the treatment of neoplasm of the Central Nervous System (CNS) and the most common tumor, glioblastoma multiforme (GBM), have been explored. In addition, an overview of the general principles of PDT, as well as the mechanism of action of the therapy as a therapeutic platform for brain tumors, is described. The research was carried out in June 2022.
脑肿瘤的治疗仍然是现代医学的一个挑战。因此，需要先进的方法，能够合理且成功地为原发性和转移性脑内肿瘤的早期诊断做出贡献。光动力疗法（PDT）似乎是一种有价值的治疗方法，可用于治疗包括脑肿瘤在内的癌前病变和癌症病变。与化疗和放疗相比，PDT 的主要优势是其高效、微创和无严重副作用。本综述通过对文章、科学信息数据库以及癌症治疗相关组织的网站进行全面搜索进行。还讨论了其他研究人员进行的临床试验的要点。使用了常见的数据库，如 PubMed、Google Scholar、EBSCO、Scopus 和 Elsevier。主要分析了具有可靠可信度的英文文章。考虑的出版物类型包括临床前和临床研究、系统评价和病例报告。基于这些收集的材料，我们可以看到科学家们已经证明了 PDT 在脑肿瘤领域应用的潜力。因此，在本综述中，探讨了中枢神经系统（CNS）肿瘤和最常见的肿瘤——多形性胶质母细胞瘤（GBM）的治疗方法。此外，还概述了 PDT 的一般原则，以及该疗法作为脑肿瘤治疗平台的作用机制。研究于 2022 年 6 月进行。
