Amino acid permeases (AAPs) are proteins of the integral membrane that play important roles in plant growth, development, and responses to various stresses. The molecular functions of several AAPs were characterized in and rice, but there is still limited information on wheat. Here, we identified 51 genes () in the wheat genome, classified into six groups based on phylogenetic and protein structures. The chromosome location and gene duplication analysis showed that gene duplication events played a crucial role in the expansion of the gene family. Collinearity relationship analysis revealed several orthologous between wheat and other species. Moreover, cis-element analysis of promoter regions and transcriptome data suggested that the can respond to salt stress. A gene was selected and transformed in wheat. Overexpressing enhanced salt tolerance by increasing the expression of ethylene synthesis genes (//) and accumulating more ethylene. The present study provides an overview of the family in the wheat genome as well as information on systematics, phylogenetics, and gene duplication, and shows that overexpressing enhances salt tolerance by regulating ethylene production. These results serve as a theoretical foundation for further functional studies on in the future.