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使用表型和基因型方法评估载脂蛋白(a)异构体大小。

Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods.

机构信息

Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.

Pathological Anatomy Department, Yerevan State Medical University, Yerevan 0025, Armenia.

出版信息

Int J Mol Sci. 2023 Sep 9;24(18):13886. doi: 10.3390/ijms241813886.

DOI:10.3390/ijms241813886
PMID:37762189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10531419/
Abstract

Apolipoprotein(a) (apo(a)) is the protein component that defines lipoprotein(a) (Lp(a)) particles and is encoded by the LPA gene. The apo(a) is extremely heterogeneous in size due to the copy number variations in the kringle-IV type 2 (KIV2) domains. In this review, we aim to discuss the role of genetics in establishing Lp(a) as a risk factor for coronary heart disease (CHD) by examining a series of molecular biology techniques aimed at identifying the best strategy for a possible application in clinical research and practice, according to the current gold standard.

摘要

载脂蛋白(a)（apo(a)）是定义脂蛋白(a)（Lp(a)）颗粒的蛋白成分，由 LPA 基因编码。apo(a) 由于kringle-IV 型 2（KIV2）结构域的拷贝数变异而在大小上极其不均一。在本综述中，我们旨在通过检查一系列旨在确定最佳策略的分子生物学技术来讨论遗传在确定 Lp(a) 作为冠心病（CHD）风险因素中的作用，根据当前的金标准，该策略可能适用于临床研究和实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7b0/10531419/50abf750039a/ijms-24-13886-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7b0/10531419/7ea22be4af3e/ijms-24-13886-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7b0/10531419/50abf750039a/ijms-24-13886-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7b0/10531419/7ea22be4af3e/ijms-24-13886-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7b0/10531419/50abf750039a/ijms-24-13886-g002.jpg

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Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods.

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[9]
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[10]
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本文引用的文献

[1]
Efficacy and safety of inclisiran a newly approved FDA drug: a systematic review and pooled analysis of available clinical studies.

Am Heart J Plus. 2022-4-2

[2]
Predictive value of lipoprotein(a) in coronary artery calcification among asymptomatic cardiovascular disease subjects: A systematic review and meta-analysis.

Nutr Metab Cardiovasc Dis. 2023-11

[3]
Association Between Lipoprotein (a) and Risk of Atrial Fibrillation: A Systematic Review and Meta-analysis of Mendelian Randomization Studies.

Curr Probl Cardiol. 2024-1

[4]
The Promise of PCSK9 and Lipoprotein(a) as Targets for Gene Silencing Therapies.

Clin Ther. 2023-11

[5]
Role of lipoprotein(a) in atherosclerotic cardiovascular disease: A review of current and emerging therapies.

Pharmacotherapy. 2023-10

[6]
Filling the gap: Genetic risk assessment in hypercholesterolemia using LDL-C and LPA genetic scores.

Clin Genet. 2023-9

[7]
Daring to dream: Targeting lipoprotein(a) as a causal and risk-enhancing factor.

Pharmacol Res. 2023-8

[8]
Lipoprotein(a): a Case for Universal Screening in Youth.

Curr Atheroscler Rep. 2023-8

[9]
SDS Electrophoresis on Gradient Polyacrylamide Gels as a Semiquantitative Tool for the Evaluation of Proteinuria.

Diagnostics (Basel). 2023-4-23

[10]
Thrombophilia screening in the routine clinical care of children with arterial ischemic stroke.

Pediatr Blood Cancer. 2023-8

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