Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Int J Mol Sci. 2023 Sep 11;24(18):13928. doi: 10.3390/ijms241813928.
A chemotherapeutic approach is crucial in malignancy management, which is often challenging due to the development of chemoresistance. Over time, chemo-resistant cancer cells rapidly repopulate and metastasize, increasing the recurrence rate in cancer patients. Targeting these destined cancer cells is more troublesome for clinicians, as they share biology and molecular cross-talks with normal cells. However, the recent insights into the metabolic profiles of chemo-resistant cancer cells surprisingly illustrated the activation of distinct pathways compared with chemo-sensitive or primary cancer cells. These distinct metabolic dynamics are vital and contribute to the shift from chemo-sensitivity to chemo-resistance in cancer. This review will discuss the important metabolic alterations in cancer cells that lead to drug resistance.
化疗方法在恶性肿瘤的治疗中至关重要，但由于化疗耐药性的发展，这往往具有挑战性。随着时间的推移，化疗耐药的癌细胞迅速增殖并转移，增加了癌症患者的复发率。对临床医生来说，靶向这些注定的癌细胞更加麻烦，因为它们与正常细胞具有相似的生物学和分子串扰。然而，最近对化疗耐药癌细胞代谢特征的深入研究表明，与化疗敏感或原发性癌细胞相比，这些细胞中存在明显激活的不同途径。这些不同的代谢动态是至关重要的，它们导致了癌细胞从化疗敏感性向化疗耐药性的转变。本综述将讨论导致药物耐药性的癌细胞中重要的代谢改变。
