Department of Orthopedics, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130000, China.
Department of Thoracic Surgery, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130000, China.
Amino Acids. 2023 Oct;55(10):1223-1246. doi: 10.1007/s00726-023-03316-y. Epub 2023 Aug 30.
Cancer malignancies may broadly be described as heterogeneous disorders manifested by uncontrolled cellular growth/division and proliferation. Tumor cells utilize metabolic reprogramming to accomplish the upregulated nutritional requirements for sustaining their uncontrolled growth, proliferation, and survival. Metabolic reprogramming also called altered or dysregulated metabolism undergoes modification in normal metabolic pathways for anabolic precursor's generation that serves to continue biomass formation that sustains the growth, proliferation, and survival of carcinogenic cells under a nutrition-deprived microenvironment. A wide range of dysregulated/altered metabolic pathways encompassing different metabolic regulators have been described; however, the current review is focused to explain deeply the metabolic pathways modifications inducing upregulation of proteins/amino acids metabolism. The essential modification of various metabolic cycles with their consequent outcomes meanwhile explored promising therapeutic targets playing a pivotal role in metabolic regulation and is successfully employed for effective target-specific cancer treatment. The current review is aimed to understand the metabolic reprogramming of different proteins/amino acids involved in tumor progression along with potential therapeutic perspective elucidating targeted cancer therapy via these targets.
癌症恶性肿瘤可以广义地描述为表现为不受控制的细胞生长/分裂和增殖的异质性疾病。肿瘤细胞利用代谢重编程来满足维持其不受控制的生长、增殖和存活所需的上调营养需求。代谢重编程也称为代谢改变或失调，发生在正常代谢途径中，用于生成合成前体，以继续形成生物量，从而在营养缺乏的微环境下维持致癌细胞的生长、增殖和存活。已经描述了广泛的代谢失调/改变途径，包括不同的代谢调节剂；然而，本综述重点深入解释诱导蛋白质/氨基酸代谢上调的代谢途径修饰。同时探索了各种代谢循环的基本修饰及其随之而来的结果，这为代谢调节中的关键治疗靶点提供了有希望的治疗靶点，并成功地用于有效的靶向特异性癌症治疗。本综述旨在了解肿瘤进展中涉及的不同蛋白质/氨基酸的代谢重编程，并通过这些靶点阐明靶向癌症治疗的潜在治疗观点。
