Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
Int J Mol Sci. 2023 Sep 11;24(18):13948. doi: 10.3390/ijms241813948.
Kawasaki disease (KD) is an acute inflammatory disorder that primarily affects children and can lead to coronary artery lesions (CAL) if not diagnosed and treated promptly. The original clinical criteria for diagnosing KD were reported by Dr. Tomisaku Kawasaki in 1967 and have been used for decades. However, research since then has highlighted the limitations of relying solely on these criteria, as they might lead to underdiagnosis or delayed diagnosis, potentially increasing the risk of coronary artery complications. This review appears to discuss several important aspects related to KD diagnosis and management. The current diagnostic methods for KD might need updates, especially considering cases that do not fit the typical clinical criteria. Recognizing diagnostic pitfalls and distinguishing KD from other conditions that might have similar clinical presentations is essential. The differences and similarities between KD and Multisystem Inflammatory Syndrome in Children (MIS-C), another inflammatory condition that has been associated with COVID-19, were also reviewed. The review explores the potential role of eosinophil count, new biomarkers, microRNA panels, and scoring systems in aiding the diagnosis of KD. Overall, the review article provides a comprehensive overview of the evolving landscape of KD diagnosis and management, incorporating new diagnostic methods, biomarkers, and treatment approaches to improve patient outcomes and reduce the risk of complications.
川崎病（KD）是一种急性炎症性疾病，主要影响儿童，如果不能及时诊断和治疗，可能导致冠状动脉病变（CAL）。川崎病的最初临床诊断标准是由 Dr. Tomisaku Kawasaki 于 1967 年报告的，几十年来一直被沿用。然而，此后的研究强调了仅依赖这些标准的局限性，因为它们可能导致漏诊或延迟诊断，从而增加冠状动脉并发症的风险。这篇综述似乎讨论了与 KD 诊断和管理相关的几个重要方面。川崎病的当前诊断方法可能需要更新，尤其是考虑到那些不符合典型临床标准的病例。识别诊断陷阱，区分 KD 与其他可能具有相似临床表现的疾病至关重要。KD 与另一种与 COVID-19 相关的炎症性疾病——儿童多系统炎症综合征（MIS-C）之间的差异和相似之处也进行了综述。该综述探讨了嗜酸性粒细胞计数、新型生物标志物、microRNA 谱和评分系统在辅助 KD 诊断中的潜在作用。总的来说，这篇综述文章全面概述了 KD 诊断和管理的不断发展，纳入了新的诊断方法、生物标志物和治疗方法，以改善患者的预后并降低并发症的风险。
