Phi Duc Long, Nguyen Thi Hoai, Duong Khanh Linh, Nguyen Le Cam Anh, Nguyen Duy Cuong, Hoang Van Thuan
Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam.
Thai Binh Pediatric Hospital, Thai Binh, Vietnam.
Front Pediatr. 2025 Jul 8;13:1490921. doi: 10.3389/fped.2025.1490921. eCollection 2025.
Infants younger than 3 months old often present with incomplete Kawasaki Disease (KD), where not all the classical features are present. This makes the diagnosis challenging, as KD may be easily confused with other common pediatric conditions, such as viral infections, bacterial sepsis, or toxic shock syndrome. Moreover, the risk of developing coronary artery abnormalities is reportedly higher in younger infants, making timely diagnosis and treatment critical. Here we reported three cases of KD in infants under three months, each illustrating the challenges in diagnosis due to the absence of typical KD symptoms such as rash, conjunctivitis, and oral mucosal changes. Echocardiography played a pivotal role in identifying coronary artery abnormalities, leading to the diagnosis of incomplete KD in all cases. Clinicians should maintain a high index of suspicion for KD in any febrile infant, particularly when inflammatory markers are elevated. Early recognition and treatment are vital to prevent severe cardiovascular complications.
3个月以下的婴儿常表现为不完全川崎病(KD),即并非所有典型特征都出现。这使得诊断具有挑战性,因为KD可能很容易与其他常见的儿科疾病混淆,如病毒感染、细菌性败血症或中毒性休克综合征。此外,据报道,小婴儿发生冠状动脉异常的风险更高,因此及时诊断和治疗至关重要。在此,我们报告了3例3个月以下婴儿的KD病例,每例都说明了由于缺乏皮疹、结膜炎和口腔黏膜变化等典型KD症状而导致的诊断挑战。超声心动图在识别冠状动脉异常方面发挥了关键作用,所有病例均据此诊断为不完全KD。临床医生应对任何发热婴儿保持高度的KD怀疑指数,尤其是当炎症标志物升高时。早期识别和治疗对于预防严重心血管并发症至关重要。