Victor Chang Cardiac Research Institute, Lowy Packer Building, Darlinghurst, NSW 2010, Australia.
St Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW 2010, Australia.
Int J Mol Sci. 2023 Sep 14;24(18):14113. doi: 10.3390/ijms241814113.
PIEZO channels PIEZO1 and PIEZO2 are the newly identified mechanosensitive, non-selective cation channels permeable to Ca. In higher vertebrates, PIEZO1 is expressed ubiquitously in most tissues and cells while PIEZO2 is expressed more specifically in the peripheral sensory neurons. PIEZO channels contribute to a wide range of biological behaviors and developmental processes, therefore driving significant attention in the effort to understand their molecular properties. One prominent property of PIEZO channels is their rapid inactivation, which manifests itself as a decrease in channel open probability in the presence of a sustained mechanical stimulus. The lack of the PIEZO channel inactivation is linked to various mechanopathologies emphasizing the significance of studying this PIEZO channel property and the factors affecting it. In the present review, we discuss the mechanisms underlying the PIEZO channel inactivation, its modulation by the interaction of the channels with lipids and/or proteins, and how the changes in PIEZO inactivation by the channel mutations can cause a variety of diseases in animals and humans.
PIEZO 通道 PIEZO1 和 PIEZO2 是新发现的机械敏感性、非选择性阳离子通道，可渗透钙离子。在高等脊椎动物中，PIEZO1 广泛表达于大多数组织和细胞中，而 PIEZO2 则更特异性地表达于周围感觉神经元中。PIEZO 通道参与了广泛的生物学行为和发育过程，因此在努力理解其分子特性方面引起了极大的关注。PIEZO 通道的一个突出特性是其快速失活，这表现为在持续机械刺激存在下通道开放概率的降低。缺乏 PIEZO 通道失活与各种机械病理有关，强调了研究这一 PIEZO 通道特性及其影响因素的重要性。在本综述中，我们讨论了 PIEZO 通道失活的机制，以及通道与脂质和/或蛋白质相互作用对其的调节，以及通道突变导致的 PIEZO 失活变化如何在动物和人类中引起多种疾病。
