Zhang Yuxi, Yang Xiaoke, Deng Simin, Wang Chenxu, Hu Jialing, Lan Qinghai
Department of Anesthesiology, Ganzhou People's Hospital, Ganzhou, China.
Jiangxi Medical School, Nanchang University, Nanchang, China.
Front Cell Neurosci. 2025 Jul 9;19:1556892. doi: 10.3389/fncel.2025.1556892. eCollection 2025.
Many physiological processes in the human body are initiated by mechanical signals, which are transmitted via ion channels. Piezo-type mechanosensitive ion channel component 1 (Piezo1) is a protein highly expressed in the brain, playing a critical role in sensing changes in the mechanical microenvironment. Extensive research has demonstrated that Piezo1 is an essential component for generating currents in mechanically activated cation channels. It is involved in several key processes in the nervous system, including neuronal development and differentiation, nerve regeneration, axon guidance, and myelination. Demyelinating diseases, characterized by the loss of nerve myelin sheaths, occur in the central or peripheral nervous system. These diseases are clinically challenging due to their diverse etiologies, multiple types, poor prognosis, and lack of definitive cures. This article aims to review the current research on the role of Piezo1 in myelination and its involvement in demyelinating diseases, as well as to explore the potential of targeting Piezo1 for therapeutic interventions in such conditions.
人体中的许多生理过程由机械信号引发，这些信号通过离子通道进行传递。压电型机械敏感离子通道组分1（Piezo1）是一种在大脑中高度表达的蛋白质，在感知机械微环境变化中发挥关键作用。广泛研究表明，Piezo1是机械激活阳离子通道中产生电流的必需组分。它参与神经系统的多个关键过程，包括神经元发育与分化、神经再生、轴突导向和髓鞘形成。脱髓鞘疾病以神经髓鞘的丧失为特征，发生在中枢或周围神经系统。这些疾病由于病因多样、类型繁多、预后不良且缺乏确切治愈方法，在临床上具有挑战性。本文旨在综述当前关于Piezo1在髓鞘形成中的作用及其与脱髓鞘疾病关系的研究，并探讨针对Piezo1进行此类疾病治疗干预的潜力。
