Benoit-Piau Justine, Tremblay Karine, Piché Alain, Dallaire Frédéric, Bélanger Mathieu, d'Entremont Marc-André, Pasquier Jean-Charles, Fortin Martin, Bourque Catherine, Lapointe Fanny, Betala-Belinga Jean-François, Petit Geneviève, Jourdan Guillaume, Bahous Renata, Maya Camilo, Benzina Amira, Faiyaz Hossain Muhammad, Peel Marie-Audrey, Houle Olivier, Auger Marie-Sandrine, Rioux Antoine, Farand Paul
Research Center of the Centre Hospitalier Universitaire de Sherbrooke (CHUS), University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Pharmacology and Physiology Department, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
J Clin Med. 2023 Sep 13;12(18):5939. doi: 10.3390/jcm12185939.
: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naïve persons remain unclear. Furthermore, the long-term consequences of these chronic symptoms on work and mental health are poorly documented. : To determine the outcome, the risk factors, and the impact on work and mental health associated with post-COVID-19 symptoms. : This prospective population-based study assessed acute COVID-19 symptoms and their evolution for up to nine months following infection. Individuals aged 18 years and older with COVID-19 in three Canadian regions between 1 November 2020 and 31 May 2021 were recruited. Participants completed a questionnaire that was either administered by trained student investigators over the phone or self-administered online. : A total of 1349 participants with a mean age of 46.6 ± 16.0 years completed the questionnaire. Participants were mostly unvaccinated at the time of their COVID-19 episode (86.9%). Six hundred and twenty-two participants (48.0%) exhibited one symptom or more, at least three months post-COVID-19. Among participants with PCC, 23.0% to 37.8% experienced fatigue at the time of survey. Moreover, 6.1% expressed psychological distress. Risk factors for PCC and fatigue included female sex (OR = 1.996), higher number of symptoms (OR = 1.292), higher severity of episode (OR = 3.831), and having a mental health condition prior to the COVID-19 episode (OR = 5.155). : In this multicenter cohort study, almost half (47%) of the participants reported persistent symptoms >3 months after acute infection. Baseline risk factors for PCC include female sex, number and severity of symptoms during acute infection, and a previous diagnosis of mental health disorder. Having PCC negatively impacted health-related quality of life and these patients were more likely to exhibit psychological distress, as well as fatigue.
急性SARS-CoV-2感染后经常会出现持续症状，这种情况被称为新冠后状况（PCC）。免疫初免人群中PCC的持续时间和严重程度尚不清楚。此外，这些慢性症状对工作和心理健康的长期影响记录不足。
为了确定新冠后症状的结果、风险因素以及对工作和心理健康的影响。
这项基于人群的前瞻性研究评估了急性新冠症状及其感染后长达九个月的演变情况。招募了2020年11月1日至2021年5月31日期间在加拿大三个地区感染新冠的18岁及以上个体。参与者完成了一份问卷，该问卷由经过培训的学生调查员通过电话进行发放或在线自行填写。
共有1349名平均年龄为46.6±16.0岁的参与者完成了问卷。参与者在感染新冠时大多未接种疫苗（86.9%）。622名参与者（48.0%）在新冠感染后至少三个月出现了一种或多种症状。在患有PCC的参与者中，23.0%至37.8%在调查时感到疲劳。此外，6.1%表示有心理困扰。PCC和疲劳的风险因素包括女性（OR = 1.996）、症状数量较多（OR = 1.292）、发作严重程度较高（OR = 3.831）以及在新冠发作前患有心理健康疾病（OR = 5.155）。
在这项多中心队列研究中，几乎一半（47%）的参与者报告在急性感染后持续症状超过3个月。PCC的基线风险因素包括女性、急性感染期间症状的数量和严重程度以及先前的心理健康障碍诊断。患有PCC对健康相关生活质量有负面影响，这些患者更有可能出现心理困扰以及疲劳。
