Shido Rena, Ohba Seigo, Tominaga Risa, Sumita Yoshinori, Asahina Izumi
Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Center for Oral Implant, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
J Clin Med. 2023 Sep 15;12(18):5994. doi: 10.3390/jcm12185994.
Biodegradable guided bone regeneration (GBR) membranes consist primarily of collagen and aliphatic polyesters. This study assessed the comparative efficacy of a poly(l-lactic-caprolactone) [P(LA/CL)] membrane versus that of a collagen membrane in GBR. Patients requiring GBR simultaneously or before dental implant placement in edentulous regions were randomly assigned to one of two membranes. Within each membrane, they were subdivided into 3 groups: dental implants were placed simultaneously with GBR in groups A and B, and 180 days post-GBR in group C. The augmented bone width was measured at 1, 3, and 6 mm from the implant's neck (groups A and B) or the reference line (group C), utilizing cone-beam computed tomography images, immediately and 150 days post-surgery. A histological study was performed to evaluate bone formation in group C. No adverse events were observed. In the collagen group, the absorbed ratios of the augmented bone were 40.9 ± 36.7%, 29.4 ± 30.1%, and 11.1 ± 22.0% at 1, 3, and 6 mm, respectively; the ratio at 6 mm was significantly lower than that at 1 mm ( = 0.0442). In the P(LA/CL) group, those were 26.2 ± 27.3%, 17.1 ± 19.7%, and 13.3 ± 16.4% at 1, 3, and 6 mm, respectively, with no significant difference at each point. No significant inter-membrane differences were observed. The bone augmentation potential of the P(LA/CL) membrane matched that of the collagen membrane. P(LA/CL) could be used as a safe and effective membrane in GBR.
可生物降解引导骨再生（GBR）膜主要由胶原蛋白和脂肪族聚酯组成。本研究评估了聚（L-乳酸-己内酯）[P（LA/CL）]膜与胶原蛋白膜在GBR中的相对疗效。在无牙区需要在种植体植入前或同时进行GBR的患者被随机分配到两种膜中的一种。在每种膜内，他们又被细分为3组：A组和B组在GBR同时植入牙种植体，C组在GBR后180天植入。利用锥形束计算机断层扫描图像，在手术后即刻和150天时，在距种植体颈部1、3和6 mm处（A组和B组）或参考线（C组）测量增加的骨宽度。对C组进行了组织学研究以评估骨形成情况。未观察到不良事件。在胶原蛋白组中，在1、3和6 mm处增加骨的吸收比例分别为40.9±36.7%、29.4±30.1%和11.1±22.0%；6 mm处的比例显著低于1 mm处（P = 0.0442）。在P（LA/CL）组中，在1、3和6 mm处分别为26.2±27.3%、17.1±19.7%和13.3±16.4%，各点之间无显著差异。未观察到膜间的显著差异。P（LA/CL）膜的骨增量潜力与胶原蛋白膜相当。P（LA/CL）可用作GBR中一种安全有效的膜。
