Ortiz-Guzmán Johan E, Mollà-Casanova Sara, Serra-Añó Pilar, Arias-Mutis Óscar J, Calvo Conrado, Bizy Alexandra, Alberola Antonio, Chorro Francisco J, Zarzoso Manuel
Department of Physiology, Universitat de València, Av. Blasco Ibáñez 15, 46010 Valencia, Spain.
Department of Physiotherapy, Universitat de València, Street Gascó Oliag 5, 46010 Valencia, Spain.
J Clin Med. 2023 Sep 19;12(18):6051. doi: 10.3390/jcm12186051.
Our aim was to determine the differences in short-term heart rate variability (HRV) between patients with metabolic syndrome (MS) and healthy controls.
We searched electronic databases for primary works with short-term HRV recordings (≤30 min) that made comparisons between individuals with MS versus healthy controls. This systematic review and meta-analysis (MA) was performed according to PRISMA guidelines and registered at PROSPERO (CRD42022358975).
Twenty-eight articles were included in the qualitative synthesis and nineteen met the criteria for the MA. Patients with MS showed decreased SDNN (-0.36 [-0.44, -0.28], < 0.001), rMSSD (-7.59 [-9.98, -5.19], < 0.001), HF (-0.36 [-0.51, -0.20], < 0.00001) and LF (-0.24 [-0.38, -0.1], = 0.001). In subsequent subanalyses, we found a decrease in SDNN (-0.99 (-1.45, -0.52], < 0.001), rMSSD (-10.18 [-16.85, -3.52], < 0.01) and HF (-1.04 [-1.97, -0.1] < 0.05) in women. In men, only LF showed a significant lower value (-0.26 [-0.5, -0.02], < 0.05). We could not perform MA for non-linear variables.
Patients with MS showed changes in time-domain analyses, with lower values in SDNN and rMSSD. Regarding frequency-domain analyses, MS patients showed a decrease in HF and LF When sex was used as a grouping variable, the MA was only possible in one of both sexes (men or women) in rMSSD and LF/HF. Lastly, when data for both men and women were available, subanalyses showed a different behavior compared to mixed analyses for SDNN, HF and LF, which might point towards a different impact of MS in men and women.
我们的目的是确定代谢综合征（MS）患者与健康对照者在短期心率变异性（HRV）方面的差异。
我们在电子数据库中搜索了有短期HRV记录（≤30分钟）且对MS个体与健康对照者进行比较的原始研究。本系统评价和荟萃分析（MA）按照PRISMA指南进行，并在PROSPERO（CRD42022358975）注册。
28篇文章纳入定性综合分析，19篇符合MA标准。MS患者的SDNN降低（-0.36 [-0.44, -0.28]，<0.001），rMSSD降低（-7.59 [-9.98, -5.19]，<0.001），HF降低（-0.36 [-0.51, -0.20]，<0.00001），LF降低（-0.24 [-0.38, -0.1]，=0.001）。在随后的亚组分析中，我们发现女性的SDNN降低（-0.99 [-1.45, -0.52]，<0.001），rMSSD降低（-10.18 [-16.85, -3.52]，<0.01），HF降低（-1.04 [-1.97, -0.1]，<0.05）。在男性中，只有LF显示出显著较低的值（-0.26 [-0.5, -0.02]，<0.05）。我们无法对非线性变量进行MA分析。
MS患者在时域分析中出现变化，SDNN和rMSSD值较低。在频域分析方面，MS患者的HF和LF降低。当将性别作为分组变量时，在rMSSD和LF/HF方面，MA分析仅在男性或女性中的一方可行。最后，当有男性和女性的数据时，亚组分析显示与SDNN、HF和LF的混合分析相比行为不同，这可能表明MS对男性和女性的影响不同。
