Popețiu Romana Olivia, Donath-Miklos Imola, Borta Simona Maria, Rus Larisa Alexandra, Vîlcea Anamaria, Nica Dragoș Vasile, Pușchiță Maria
Department of Internal Medicine, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.
Arad County Emergency Clinical Hospital, Str. Andrényi Károly Nr. 2-4, 310037 Arad, Romania.
J Clin Med. 2023 Sep 21;12(18):6106. doi: 10.3390/jcm12186106.
Little information exists on YKL-40-a key protein in tissue remodeling-and complete blood count (CBC) parameters during acute exacerbations of advanced chronic obstructive pulmonary disease (COPD). This pilot exploratory study (August 2020-January 2021) investigated the connection between serum YKL-40 levels and CBC profile in sex- and age-matched individuals with severe COPD (GOLD stage III, = 23, median age = 66 years, 65.21% males) and very severe COPD (GOLD stage IV, = 24, median age = 66.5 years, 74.81% males). The measured parameters were serum YKL-40, absolute leukocyte count (ALLC), absolute neutrophil count (ANC), neutrophil percentage, absolute lymphocyte count (ALC), lymphocyte percentage, neutrophil-to-lymphocyte ratio (NLR), absolute eosinophil count (AEC), eosinophil percentage, absolute monocyte count (AMC), monocyte percentage, absolute basophil count (ABC), basophil percentage, hemoglobin levels, and hematocrit concentrations. No significant inter-group differences were observed. However, high YKL-40 subjects ( = 23)-as stratified via median YKL-40 (3934.5 pg/mL)-showed significantly increased neutrophil percentage and NLR but significantly lower lymphocyte-, eosinophil-, and basophil-related parameters compared to low YKL-40 patients ( = 24). These results reveal multidimensional, YKL-40-associated changes in leukocyte profile of patients with advanced COPD during acute exacerbations, with potential implications for personalized treatment.
关于YKL-40（组织重塑中的一种关键蛋白）以及晚期慢性阻塞性肺疾病（COPD）急性加重期全血细胞计数（CBC）参数的信息较少。这项探索性初步研究（2020年8月至2021年1月）调查了年龄和性别匹配的重度COPD患者（GOLD III期，n = 23，中位年龄 = 66岁，男性占65.21%）和极重度COPD患者（GOLD IV期，n = 24，中位年龄 = 66.5岁，男性占74.81%）血清YKL-40水平与CBC指标之间的关联。所测量的参数包括血清YKL-40、白细胞绝对计数（ALLC）、中性粒细胞绝对计数（ANC）、中性粒细胞百分比、淋巴细胞绝对计数（ALC）、淋巴细胞百分比、中性粒细胞与淋巴细胞比值（NLR）、嗜酸性粒细胞绝对计数（AEC）、嗜酸性粒细胞百分比、单核细胞绝对计数（AMC）、单核细胞百分比、嗜碱性粒细胞绝对计数（ABC）、嗜碱性粒细胞百分比、血红蛋白水平和血细胞比容浓度。未观察到显著的组间差异。然而，与低YKL-40患者（n = 24）相比，通过YKL-40中位数（3934.5 pg/mL）分层的高YKL-40受试者（n = 23）显示中性粒细胞百分比和NLR显著升高，但淋巴细胞、嗜酸性粒细胞和嗜碱性粒细胞相关参数显著降低。这些结果揭示了晚期COPD患者急性加重期白细胞谱中与YKL-40相关的多维变化，对个性化治疗具有潜在意义。
