Sundaram Vijaya Lakshmi, Lamichhane Rajan, Cecchetti Alfred, Arthur Subha, Murughiyan Usha
Department of Clinical and Translational Sciences, Marshall University School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA.
Department of Internal Medicine, Marshall University School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA.
Life (Basel). 2023 Sep 19;13(9):1933. doi: 10.3390/life13091933.
Metabolic syndrome amplifies the risk of gestational diabetes, preeclampsia, and preterm labor in pregnant women. Similarly, women with substance use disorder have worsened obstetric and birth outcomes. Despite these two conditions being major healthcare disparities in Appalachia, the health outcomes of this cohort have not been studied thus far. This study looks at the health outcomes of this cohort.
In this retrospective cohort study, we analyzed 27,955 mothers who delivered at Cabell Huntington Hospital between January 2010 and November 2021. We implemented Chi-square tests to determine the associations and multiple logistic regression methods for comparison after controlling for other factors, and found that MetS, together with SUD, significantly increases the risk as well as the number of pregnancy complications such as gestational diabetes (-value < 0.001), preeclampsia (-value < 0.001), premature rupture (-value < 0.001), preterm labor (-value < 0.001), and newborn disorder (-value < 0.001) compared to the women who had none or had either MetS or SUD alone.
Women with both metabolic syndrome and substance abuse had worsened pregnancy and neonatal outcomes compared to women with metabolic syndrome or SUD alone. In conclusion, analysis of all the variables is crucial to strategically planning and implementing health interventions that will positively influence the health outcome of the pregnant woman as well as the child.
代谢综合征会增加孕妇患妊娠期糖尿病、先兆子痫和早产的风险。同样，患有物质使用障碍的女性产科和分娩结局会更差。尽管这两种情况是阿巴拉契亚地区主要的医疗保健差异，但迄今为止尚未对该队列人群的健康结局进行研究。本研究着眼于该队列人群的健康结局。
在这项回顾性队列研究中，我们分析了2010年1月至2021年11月期间在卡贝尔·亨廷顿医院分娩的27955名母亲。我们采用卡方检验来确定关联，并采用多元逻辑回归方法在控制其他因素后进行比较，发现与既没有代谢综合征（MetS）也没有物质使用障碍（SUD）或仅患有其中一种疾病的女性相比，代谢综合征与物质使用障碍共同存在会显著增加妊娠并发症的风险以及并发症的数量，如妊娠期糖尿病（p值<0.001）、先兆子痫（p值<0.001）、胎膜早破（p值<0.001）、早产（p值<0.001）和新生儿疾病（p值<0.001）。
与仅患有代谢综合征或物质使用障碍的女性相比，同时患有代谢综合征和物质滥用的女性妊娠和新生儿结局更差。总之，对所有变量进行分析对于制定和实施能够对孕妇及儿童的健康结局产生积极影响的健康干预措施至关重要。
