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富血小板血浆(PRP)治疗对子宫内膜厚度和不孕的疗效:罗马尼亚单中心经验。

Autologous Platelet-Rich Plasma (PRP) Efficacy on Endometrial Thickness and Infertility: A Single-Centre Experience from Romania.

机构信息

Faculty of Medicine and Pharmacy, University of Oradea, 1St December Square 10, 410073 Oradea, Romania.

Calla-Infertility Diagnostic and Treatment Center, Constantin A. Rosetti Street, 410103 Oradea, Romania.

出版信息

Medicina (Kaunas). 2023 Aug 24;59(9):1532. doi: 10.3390/medicina59091532.

Abstract

(1) : During IVF (in vitro fertilization), a proper endometrium thickness is one of the most difficult parameters to achieve and one of the most important prognostic factors of the success rate. One major problem is the high cancelation percentage in frozen embryo transfer cycles. The focus on the adjuvant methods for improving endometrium thickness is an on-going subject of interest. (2) : This prospective single-arm self-control study was conducted in an IVF centre in Oradea, Romania. The patients were divided into two groups. The control group included 51 patients with at least one attempt to transfer a good-quality blastocyst, but the endometrial thickness did not surpass 7 mm under standard endometrial preparation protocol with oestradiol and with adjuvant therapy (other than PRP, such as aspirin, vitamin C, and vitamin E), and the study group included the same 51 patients that had the embryo transfer performed under the same standard endometrial preparation protocol with oestradiol preparation protocol and intrauterine PRP infusion. (3) : In our study, the PRP treatment had a positive impact on the parameters that were followed for the evaluation of the success rate of the embryo transfer procedure. The endometrial thickness (an increase in endometrial thickness by 0.6 mm after PRP treatment with = 0.0001) and the clinical pregnancy rate (having a MD ± SD of 0 ± 0.38 before PRP treatment and with an increase to 0.5 ± 0.1 after the PRP treatment, = 0.0004) were statistically significant (4) : PRP has a positive effect in promoting endometrial proliferation, improving embryo implantation rate and clinical pregnancy rate for women with thin endometrium.

摘要

(1):在体外受精(IVF)过程中,合适的子宫内膜厚度是最难达到的参数之一,也是成功率的最重要预测因素之一。一个主要问题是冷冻胚胎移植周期的高取消率。关注辅助方法以提高子宫内膜厚度是一个持续关注的课题。

(2):本前瞻性单臂自身对照研究在罗马尼亚奥拉迪亚的一家试管婴儿中心进行。患者分为两组。对照组包括 51 名患者,他们至少有一次尝试转移优质囊胚,但在标准雌二醇子宫内膜准备方案和辅助治疗(除 PRP 外,如阿司匹林、维生素 C 和维生素 E)下,子宫内膜厚度不超过 7 毫米,研究组包括 51 名相同的患者,他们在相同的标准雌二醇子宫内膜准备方案和宫内 PRP 输注下进行胚胎移植。

(3):在我们的研究中,PRP 治疗对胚胎移植过程成功率评估的参数有积极影响。子宫内膜厚度(PRP 治疗后子宫内膜厚度增加 0.6 毫米, = 0.0001)和临床妊娠率(PRP 治疗前的 MD ± SD 为 0 ± 0.38,治疗后增加到 0.5 ± 0.1, = 0.0004)具有统计学意义。

(4):PRP 对薄型子宫内膜妇女的子宫内膜增殖有积极作用,可提高胚胎着床率和临床妊娠率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba73/10533168/e14299b93b16/medicina-59-01532-g001.jpg

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