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气肿性肝炎的诊断与管理,重点关注生物病理学

Diagnostic and Management of Emphysematous Hepatitis with Emphasis on Biopathology.

作者信息

Porez Déborah, Kallel Hatem, Dobian Succes, Gerbert-Ferrendier Timotée, Nacher Mathieu, Djossou Félix, Demar Magalie, Amroun Hakim, Zappa Magaly, Drak Alsibai Kinan

机构信息

Unité des Maladies Infectieuses Tropicales (UMIT), Cayenne Hospital Centre, F-97306 Cayenne, France.

Réanimation Polyvalente, Pôle Urgences-Soins Critiques, Cayenne Hospital Centre, F-97306 Cayenne, France.

出版信息

Microorganisms. 2023 Aug 23;11(9):2137. doi: 10.3390/microorganisms11092137.

Abstract

Emphysematous hepatitis is a rare infectious disease, which corresponds to the presence of gas in the liver, without collection and after exclusion of vascular origin. This entity belongs to the group of emphysematous infections, whose physiopathology seems to be linked to the presence of unbalanced diabetes and to bacterial fermentation, leading to the production of gas within the liver parenchyma. Very few cases of emphysematous hepatitis have been described in the literature, and most of them had a rapidly fatal course. In this manuscript, we report the case of a 59-year-old man with emphysematous hepatitis due to wild-type that was successfully managed by surgery, and we perform a review of the literature to describe the clinical and biopathological aspects of this rare hepatic disease. Our manuscript underlines the need to perform biological and histopathological sampling to better understand the pathophysiology of this rare entity. The causes and mechanisms of emphysematous hepatitis, which seem to be multiple, lead us to believe that it is a syndrome rather than a simple infectious disease.

摘要

气肿性肝炎是一种罕见的感染性疾病,表现为肝脏内出现气体,无液体积聚且排除血管源性。该疾病属于气肿性感染范畴,其病理生理学似乎与糖尿病失衡及细菌发酵有关,导致肝实质内产生气体。文献中报道的气肿性肝炎病例极少,且大多数病例病程进展迅速并致命。在本论文中,我们报告了一例59岁因野生型导致气肿性肝炎的男性患者,经手术成功治疗,并且我们对文献进行了综述以描述这种罕见肝脏疾病的临床和生物病理学特征。我们的论文强调了进行生物学和组织病理学采样以更好理解这种罕见疾病病理生理学的必要性。气肿性肝炎的病因和机制似乎多种多样,这使我们认为它是一种综合征而非单纯的感染性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d0b/10536469/050032003cf1/microorganisms-11-02137-g001.jpg

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