Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China.
College of Pharmacy, Yanbian University, Yanji 133000, China.
Molecules. 2023 Sep 11;28(18):6564. doi: 10.3390/molecules28186564.
(Rupr. & Maxim.) S.Y.Hu (), a member of the Araliaceae family, is a valuable plant widely used for medicinal and dietary purposes. The tender shoots of are commonly consumed as a staple wild vegetable. The fruits of , known for their rich flavor, play a crucial role in the production of beverages and fruit wines. The root barks of are renowned for their therapeutic effects, including dispelling wind and dampness, strengthening tendons and bones, promoting blood circulation, and removing stasis. To compile a comprehensive collection of information on , extensive searches were conducted in databases such as Web of Science, PubMed, ProQuest, and CNKI. This review aims to provide a detailed exposition of from various perspectives, including phytochemistry and pharmacological effects, to lay a solid foundation for further investigations into its potential uses. Moreover, this review aims to introduce innovative ideas for the rational utilization of resources and the efficient development of related products. To date, a total of 314 compounds have been isolated and identified from , encompassing terpenoids, phenylpropanoids, flavonoids, volatile oils, organic acids and their esters, nitrogenous compounds, quinones, phenolics, and carbohydrates. Among these, triterpenoids and phenylpropanoids are the primary bioactive components, with containing unique 3,4-seco-lupane triterpenoids. These compounds have demonstrated promising properties such as anti-oxidative stress, anti-aging, antiplatelet aggregation, and antitumor effects. Additionally, they show potential in improving glucose metabolism, cardiovascular systems, and immune systems. Despite some existing basic research on , further investigations are required to enhance our understanding of its mechanisms of action, quality assessment, and formulation studies. A more comprehensive investigation into is warranted to delve deeper into its mechanisms of action and potentially expand its pharmaceutical resources, thus facilitating its development and utilization.
(Rupr. & Maxim.) S.Y.Hu，五加科的一员，是一种有价值的植物，广泛用于药用和食用目的。 的嫩茎通常被当作主食野生蔬菜食用。 的果实，以其浓郁的风味而闻名，在饮料和果酒生产中起着至关重要的作用。 的根皮以其祛风除湿、强筋壮骨、活血化瘀、祛瘀等治疗功效而闻名。为了全面收集 的信息，在 Web of Science、PubMed、ProQuest 和 CNKI 等数据库中进行了广泛的搜索。本综述旨在从植物化学和药理作用等多个角度详细阐述 ，为进一步研究其潜在用途奠定基础。此外，本综述旨在为 资源的合理利用和相关产品的高效开发引入创新思路。截至目前，已从 中分离鉴定出 314 种化合物，包括萜类、苯丙素类、黄酮类、挥发油、有机酸及其酯类、含氮化合物、醌类、酚类和碳水化合物。其中，三萜类和苯丙素类是主要的生物活性成分， 含有独特的 3,4-断环羊毛甾烷三萜类。这些化合物具有抗氧化应激、抗衰老、抗血小板聚集和抗肿瘤等有前途的特性。此外，它们在改善葡萄糖代谢、心血管系统和免疫系统方面也有潜在的作用。尽管对 进行了一些基础研究，但仍需要进一步研究以加深我们对其作用机制、质量评估和制剂研究的理解。需要更全面地研究 ，以深入了解其作用机制，并有可能扩大其药物资源，从而促进其开发和利用。
