Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt.
Department of Chemistry and Biochemistry, Augusta University, Augusta, GA 30912, USA.
Molecules. 2023 Sep 13;28(18):6603. doi: 10.3390/molecules28186603.
The COVID-19 pandemic has posed a significant threat to society in recent times, endangering human health, life, and economic well-being. The disease quickly spreads due to the highly infectious SARS-CoV-2 virus, which has undergone numerous mutations. Despite intense research efforts by the scientific community since its emergence in 2019, no effective therapeutics have been discovered yet. While some repurposed drugs have been used to control the global outbreak and save lives, none have proven universally effective, particularly for severely infected patients. Although the spread of the disease is generally under control, anti-SARS-CoV-2 agents are still needed to combat current and future infections. This study reviews some of the most promising repurposed drugs containing indolyl heterocycle, which is an essential scaffold of many alkaloids with diverse bio-properties in various biological fields. The study also discusses natural and synthetic indole-containing compounds with anti-SARS-CoV-2 properties and computer-aided drug design (in silico studies) for optimizing anti-SARS-CoV-2 hits/leads.
新冠疫情对当今社会构成了重大威胁，危及人类健康、生命和经济福祉。由于高度传染性的 SARS-CoV-2 病毒发生了多次突变，该疾病传播迅速。尽管自 2019 年出现以来科学界进行了大量研究，但尚未发现有效的治疗方法。虽然一些已被重新利用的药物已被用于控制全球疫情和拯救生命，但没有一种药物被证明普遍有效，特别是对严重感染的患者。虽然该疾病的传播总体上得到了控制，但仍需要抗 SARS-CoV-2 药物来对抗当前和未来的感染。本研究综述了一些最有前途的含有吲哚杂环的再利用药物，吲哚杂环是许多具有不同生物特性的生物碱的重要骨架，存在于各种生物领域。本研究还讨论了具有抗 SARS-CoV-2 特性的天然和合成含吲哚化合物，以及计算机辅助药物设计（计算机模拟研究），以优化抗 SARS-CoV-2 的命中/先导化合物。
