Gu Guochao, Li Yibo, Zuo Kangqing, Xiao Guiyong
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan 250061, China.
School of Materials Science and Engineering, Shandong University, Jinan 250061, China.
Molecules. 2023 Sep 16;28(18):6651. doi: 10.3390/molecules28186651.
Strontium (Sr) is a trace element in the human body that can promote bone formation and inhibit bone absorption. A conversion coating of strontium phosphate (Sr-P) on the surface of titanium (Ti) can improve its biological properties and has many potential applications in the fields of dentistry and orthopedics. In the present study, Sr-P coatings with SrHPO and Sr(PO) crystals on Ti are prepared by a phosphate chemical conversion (PCC) treatment and the effect of pH values on the properties of the Sr-P coatings is researched. The results prove that the phase composition, morphology, and corrosion resistance of the coated Ti vary according to the pH values of the PCC solution. The morphology of the conversion deposition on Ti changes from plat-like to cluster-like and then to homogeneous microcrystals as the pH value changes from 2.50 to 3.25. Only discrete SrHPO crystals are generated on the substrate at lower pH values, while relatively stable Sr(PO) and SrHPO crystals grow and subsequently form an integrated coating on the Ti as the pH exceeds 2.50. The cross-sectional morphologies and bonding strength of different coatings are also researched. The corrosion resistance of coated Ti improves compared with that of bare Ti because of the Sr-P coatings with a Sr(PO) phase. In addition, it is indicated that the Sr-P coatings on Ti can improve the adhesion and differentiation of BMSCs.
锶（Sr）是人体中的一种微量元素，能够促进骨形成并抑制骨吸收。钛（Ti）表面的磷酸锶（Sr-P）转化涂层可以改善其生物学性能，在牙科和骨科领域有许多潜在应用。在本研究中，通过磷酸盐化学转化（PCC）处理在Ti上制备了含有SrHPO和Sr(PO)晶体的Sr-P涂层，并研究了pH值对Sr-P涂层性能的影响。结果表明，涂层Ti的相组成、形态和耐腐蚀性随PCC溶液的pH值而变化。随着pH值从2.50变化到3.25，Ti上转化沉积物的形态从片状变为簇状，然后变为均匀的微晶。在较低pH值下，基材上仅生成离散的SrHPO晶体，而当pH超过2.50时，相对稳定的Sr(PO)和SrHPO晶体生长并随后在Ti上形成完整的涂层。还研究了不同涂层的横截面形态和结合强度。由于具有Sr(PO)相的Sr-P涂层，涂层Ti的耐腐蚀性与裸Ti相比有所提高。此外，结果表明Ti上的Sr-P涂层可以改善骨髓间充质干细胞（BMSCs）的黏附与分化。
