Banawas Saeed S, Alobaidi Ahmed S, Dawoud Turki M, AlDehaimi Abdullah, Alsubaie Faisal M, Abdel-Hadi Ahmed, Manikandan Palanisamy
Department of Medical Laboratories, College of Applied Medical Science, Majmaah University, Al-Majmaah 11952, Saudi Arabia.
Health and Basic Sciences Research Center, Majmaah University, Al-Majmaah 11952, Saudi Arabia.
Pathogens. 2023 Aug 23;12(9):1075. doi: 10.3390/pathogens12091075.
Bloodstream infection (BSI) prevalence in hospitalized patients has increased owing to the spread of antibiotic-resistant pathogens; moreover, antimicrobial resistance in bacteria is a global problem. Here, BSIs are investigated in several patients at a hospital in Saudi Arabia, and the resistance of bacterial isolates to widely used drugs is determined. Throughout 2020, bacteria isolated from patients were identified and subjected to antibiotic susceptibility testing. In total, 1125 bacterial isolates were obtained from 1039 patients; among them, gram-positive bacteria were significantly more abundant than gram-negative bacteria. The most prevalent bacteria were and . Notably, gram-negative bacteria were mainly isolated from adult patients, and 20.63% of the gram-positive isolates were from pediatric patients, which was significantly higher than the corresponding percentages in elders and adults. The gram-positive isolates were mainly resistant to cephalothin, oxacillin, amoxicillin-clavulanate, and erythromycin and susceptible to penicillin, gentamicin, ciprofloxacin, and vancomycin. Additionally, the gram-negative isolates were mainly resistant to ampicillin, cephalothin, and amoxicillin-clavulanate and susceptible to amikacin, ertapenem, aztreonam, colistin, and trimethoprim-sulfamethoxazole. Consequently, the high prevalence of infective multidrug-resistant bacteria may account as a significant health issue; it is considered a hazard in Riyadh hospitals and must be prevented at all costs.
由于抗生素耐药性病原体的传播，住院患者的血流感染（BSI）患病率有所上升；此外，细菌中的抗菌药物耐药性是一个全球性问题。在此，对沙特阿拉伯一家医院的几名患者的血流感染情况进行了调查，并确定了细菌分离株对广泛使用药物的耐药性。在2020年全年，对从患者身上分离出的细菌进行了鉴定并进行了药敏试验。总共从1039名患者身上获得了1125株细菌分离株；其中，革兰氏阳性菌比革兰氏阴性菌明显更为丰富。最常见的细菌是 和 。值得注意的是，革兰氏阴性菌主要从成年患者中分离得到，而20.63%的革兰氏阳性分离株来自儿科患者，这一比例明显高于老年人和成年人中的相应比例。革兰氏阳性分离株主要对头孢噻吩、苯唑西林、阿莫西林 - 克拉维酸和红霉素耐药，而对青霉素、庆大霉素、环丙沙星和万古霉素敏感。此外，革兰氏阴性分离株主要对氨苄西林、头孢噻吩和阿莫西林 - 克拉维酸耐药，而对阿米卡星、厄他培南、氨曲南、黏菌素和甲氧苄啶 - 磺胺甲恶唑敏感。因此，感染性多重耐药菌的高患病率可能是一个重大的健康问题；在利雅得的医院中被视为一种危害，必须不惜一切代价加以预防。
