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一种含有非挥发性多酚的提取物对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）具有杀病毒活性，在pH值升高的条件下这种活性会增强。

An Extract Containing Nonvolatile Polyphenols Shows Virucidal Activity against SARS-CoV-2 That Is Enhanced in Increased pH Conditions.

作者信息

Maaroufi Imane, Jamsransuren Dulamjav, Hashida Koh, Matsuda Sachiko, Ogawa Haruko, Takeda Yohei

机构信息

Graduate School of Animal and Veterinary Sciences and Agriculture, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan.

Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan.

出版信息

Pathogens. 2023 Aug 28;12(9):1093. doi: 10.3390/pathogens12091093.

DOI:10.3390/pathogens12091093
PMID:37764901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10534523/
Abstract

Researching the beneficial health properties of wood byproducts can prevent wastage by turning them into valuable resources. In this study, the virucidal activity of two extracts from byproducts, ASE1, and ASE2, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was investigated. ASE1 is rich in monoterpenoid volatile compounds, whereas ASE2 contains nonvolatile polyphenols. SARS-CoV-2 solutions were mixed with ASE1 or ASE2, and viral titer reduction was evaluated. At their original acidic pH, ASE2 showed stronger virucidal activity than ASE1. The virucidal activity of ASE2 was also significantly enhanced when pH was increased to neutral or basic, which was not the case for ASE1. At a neutral pH, ASE2 induced statistically significant viral titer reduction in 1 min. HCl and NaOH solutions, which had a pH close to that of acidic and basic ASE2 test mixtures, respectively, exhibited no virucidal activity against SARS-CoV-2. Among the SARS-CoV-2 variants, Omicron showed the highest vulnerability to ASE2. Western blotting, RT-PCR, and electron microscopic analysis revealed that neutral ASE2 interacts with SARS-CoV-2 spike proteins and moderately disrupts the SARS-CoV-2 genome and viral envelope. These findings reveal the virucidal potential of ASE2.

摘要

研究木材副产品的有益健康特性可以将它们转化为有价值的资源，从而防止浪费。在本研究中，研究了两种副产品提取物ASE1和ASE2对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的杀病毒活性。ASE1富含单萜类挥发性化合物，而ASE2含有非挥发性多酚。将SARS-CoV-2溶液与ASE1或ASE2混合，并评估病毒滴度降低情况。在其原始酸性pH值下，ASE2显示出比ASE1更强的杀病毒活性。当pH值提高到中性或碱性时，ASE2的杀病毒活性也显著增强，而ASE1则不然。在中性pH值下，ASE2在1分钟内可使病毒滴度显著降低。pH值分别接近酸性和碱性ASE2测试混合物的HCl和NaOH溶液对SARS-CoV-2没有杀病毒活性。在SARS-CoV-2变体中，奥密克戎对ASE2表现出最高的敏感性。蛋白质免疫印迹、逆转录聚合酶链反应和电子显微镜分析表明，中性ASE2与SARS-CoV-2刺突蛋白相互作用，并适度破坏SARS-CoV-2基因组和病毒包膜。这些发现揭示了ASE2的杀病毒潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/9d67a30fff4f/pathogens-12-01093-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/9ad473f3a467/pathogens-12-01093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/8aef9f5b3ca2/pathogens-12-01093-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/ac836d526463/pathogens-12-01093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/03a787bd60a1/pathogens-12-01093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/4e7947796080/pathogens-12-01093-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/4ec5a3d0087c/pathogens-12-01093-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/b24cf4ac6c0d/pathogens-12-01093-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/9d67a30fff4f/pathogens-12-01093-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/9ad473f3a467/pathogens-12-01093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/8aef9f5b3ca2/pathogens-12-01093-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/ac836d526463/pathogens-12-01093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/03a787bd60a1/pathogens-12-01093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/4e7947796080/pathogens-12-01093-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/4ec5a3d0087c/pathogens-12-01093-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/b24cf4ac6c0d/pathogens-12-01093-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ca/10534523/9d67a30fff4f/pathogens-12-01093-g008.jpg

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