Lopez-Campos José Luis, Reinoso-Arija Rocio, Ferrer Galván Marta, Romero Falcón Auxiliadora, Alvarez-Gutiérrez Francisco J, Ortega-Ruiz Francisco, Quintana-Gallego Esther
Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla, IBiS, Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 41013 Seville, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Pharmaceutics. 2023 Aug 26;15(9):2206. doi: 10.3390/pharmaceutics15092206.
Currently, there is a considerable degree of confusion over the dosage of inhaled medications. Here, we carried out a review of all the doses used for the devices used in inhalation therapy.
We first performed a systematic search of the different inhalation devices included on the July 2023 Spanish Ministry of Health Billing List. We then consulted the Spanish Agency for Medicines and Health Products to find the updated official label and to obtain the information on the exact composition.
We identified 90 unique products, of which 22 were long-acting bronchodilators (and combinations thereof) and 68 were products containing inhaled corticosteroids (ICS). Overall, 10 products with bronchodilators and 40 with ICS were marketed with the metered dose, while 11 with bronchodilators and 28 with ICS were marketed with the delivered dose. In addition, in some bronchodilators, the drug was referred to as a type of salt, whereas in others the information referred to the drug itself.
Our data show that for each inhaled drug there may be up to four different doses and that the marketed name may refer to any of these. Clinicians must be aware of these different dosages when prescribing inhaled medications.
目前，吸入药物的剂量存在相当程度的混乱。在此，我们对吸入疗法中使用的设备所采用的所有剂量进行了综述。
我们首先对2023年7月西班牙卫生部计费清单中包含的不同吸入设备进行了系统检索。然后，我们咨询了西班牙药品和健康产品管理局，以获取最新的官方标签并获得有关确切成分的信息。
我们识别出90种独特的产品，其中22种是长效支气管扩张剂（及其组合），68种是含有吸入性糖皮质激素（ICS）的产品。总体而言，10种含支气管扩张剂的产品和40种含ICS的产品以定量剂量销售，而11种含支气管扩张剂的产品和28种含ICS的产品以递送剂量销售。此外，在一些支气管扩张剂中，药物被称为某种盐类，而在其他产品中，信息提及的是药物本身。
我们的数据表明，每种吸入药物可能有多达四种不同的剂量，且市售名称可能指其中任何一种。临床医生在开具吸入药物处方时必须了解这些不同的剂量。
