Goldie P, Hellström S
Acta Otolaryngol. 1986 Sep-Oct;102(3-4):248-56. doi: 10.3109/00016488609108674.
The blowing of chilled (14 degrees C) air into the external auditory canal (EAC) resulted in a profuse middle ear fluid production. The stimulation caused marked changes in the pars flaccida of the tympanic membrane. A slight vasodilatation was noted in the oedematous loose connective tissue layer of the pars flaccida. The abundant mast cells showed no signs of degranulation. When stimulating animals with air at 22 degrees C, only minimal effusion production and tympanic membrane changes could be induced. At 34 degrees C, no changes occurred at all. Thus it was shown that temperature is an important factor when provoking middle ear effusion by stimulating the EAC. As fluid production is one of the major signs in OME, one may speculate whether temperature may be an overlooked etiologic agent in this disease.
向外耳道（EAC）吹入14摄氏度的冷空气会导致中耳大量积液。这种刺激导致鼓膜松弛部出现明显变化。在鼓膜松弛部水肿的疏松结缔组织层中观察到轻微的血管扩张。大量肥大细胞未显示出脱颗粒迹象。当用22摄氏度的空气刺激动物时，仅能诱导出极少的积液产生和鼓膜变化。在34摄氏度时，根本没有变化。因此表明，通过刺激外耳道诱发中耳积液时，温度是一个重要因素。由于积液产生是分泌性中耳炎的主要体征之一，人们可能会推测温度是否可能是该疾病中一个被忽视的病因。
