Beran M, Petruson B
Acta Otolaryngol. 1986 Sep-Oct;102(3-4):308-14. doi: 10.3109/00016488609108681.
121 habitual nose-bleeders were investigated. In all but one, local changes were found in the nasal mucosa. Abnormal vessels (varicose vessels, telangioma, or a network of small vessels) were found in 102 (84%), and 18 (15%) had mucosal atrophy (rhinitis anterior sicca or septal perforation) without abnormal vessels. The occurrence of abnormal vessels was significantly increased when the bleeders were compared with subjects in a control group. Mucosal atrophy was also significantly more common in the habitual nose-bleeders but only in association with abnormal vessels. Varicose vessels were the most frequent abnormality in both the habitual nose-bleeders and the control group. Telangiomas were only present in the habitual nose-bleeders. Heredity seems to be important in explaining the occurrence of varicose vessels as well as telangiomas in habitual nose-bleeders.
对121名习惯性鼻出血患者进行了调查。除1人外，其余患者均发现鼻腔黏膜有局部改变。102人（84%）发现有异常血管（静脉曲张、毛细血管扩张或小血管网），18人（15%）有黏膜萎缩（干性鼻炎或鼻中隔穿孔）但无异常血管。与对照组受试者相比，鼻出血患者中异常血管的发生率显著增加。黏膜萎缩在习惯性鼻出血患者中也明显更常见，但仅与异常血管有关。静脉曲张是习惯性鼻出血患者和对照组中最常见的异常情况。毛细血管扩张仅出现在习惯性鼻出血患者中。遗传因素似乎对解释习惯性鼻出血患者中静脉曲张和毛细血管扩张的发生很重要。
