Yan Jun, Huang Lei, Feng Juan, Yang Xue
Department of Neurology, Fushun Central Hospital, Fushun 113000, China.
Department of Cardiac Function, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Pharmaceutics. 2023 Sep 14;15(9):2322. doi: 10.3390/pharmaceutics15092322.
With the accelerated development of nanotechnology in recent years, nanomaterials have become increasingly prevalent in the medical field. The poly (lactic acid-glycolic acid) copolymer (PLGA) is one of the most commonly used biodegradable polymers. It is biocompatible and can be fabricated into various nanostructures, depending on requirements. Ischemic stroke is a common, disabling, and fatal illness that burdens society. There is a need for further improvement in the diagnosis and treatment of this disease. PLGA-based nanostructures can facilitate therapeutic compounds' passage through the physicochemical barrier. They further provide both sustained and controlled release of therapeutic compounds when loaded with drugs for the treatment of ischemic stroke. The clinical significance and potential of PLGA-based nanostructures can also be seen in their applications in cell transplantation and imaging diagnostics of ischemic stroke. This paper summarizes the synthesis and properties of PLGA and reviews in detail the recent applications of PLGA-based nanostructures for drug delivery, disease therapy, cell transplantation, and the imaging diagnosis of ischemic stroke.
近年来，随着纳米技术的加速发展，纳米材料在医学领域越来越普遍。聚（乳酸-乙醇酸）共聚物（PLGA）是最常用的可生物降解聚合物之一。它具有生物相容性，可根据需要制成各种纳米结构。缺血性中风是一种常见、致残且致命的疾病，给社会带来负担。这种疾病的诊断和治疗需要进一步改进。基于PLGA的纳米结构可以促进治疗性化合物穿过物理化学屏障。当负载药物用于治疗缺血性中风时，它们还能进一步实现治疗性化合物的持续和控释。基于PLGA的纳米结构在缺血性中风的细胞移植和成像诊断中的应用也体现了其临床意义和潜力。本文总结了PLGA的合成与性质，并详细综述了基于PLGA的纳米结构在药物递送、疾病治疗、细胞移植以及缺血性中风成像诊断方面的最新应用。
