Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, Netherlands.
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, Netherlands; Department of Biomedical Engineering, Laboratory of Immunoengineering, Eindhoven University of Technology, Eindhoven, Netherlands.
Acta Biomater. 2018 Jun;73:38-51. doi: 10.1016/j.actbio.2018.04.006. Epub 2018 Apr 11.
Nano- and microparticles have increasingly widespread applications in nanomedicine, ranging from drug delivery to imaging. Poly(lactic-co-glycolic acid) (PLGA) particles are the most widely-applied type of particles due to their biocompatibility and biodegradability. Here, we discuss the preparation of PLGA particles, and various modifications to tailor particles for applications in biological systems. We highlight new preparation approaches, including microfluidics and PRINT method, and modifications of PLGA particles resulting in novel or responsive properties, such as Janus or upconversion particles. Finally, we describe how the preparation methods can- and should-be adapted to tailor the properties of particles for the desired biomedical application. Our aim is to enable researchers who work with PLGA particles to better appreciate the effects of the selected preparation procedure on the final properties of the particles and its biological implications.
Nanoparticles are increasingly important in the field of biomedicine. Particles made of polymers are in the spotlight, due to their biodegradability, biocompatibility, versatility. In this review, we aim to discuss the range of formulation techniques, manipulations, and applications of poly(lactic-co-glycolic acid) (PLGA) particles, to enable a researcher to effectively select or design the optimal particles for their application. We describe the various techniques of PLGA particle synthesis and their impact on possible applications. We focus on recent developments in the field of PLGA particles, and new synthesis techniques that have emerged over the past years. Overall, we show how the chemistry of PLGA particles can be adapted to solve pressing biological needs.
纳米和微粒在纳米医学中的应用越来越广泛，从药物输送到成像。由于其生物相容性和可生物降解性，聚（乳酸-共-乙醇酸）（PLGA）颗粒是应用最广泛的颗粒类型。在这里，我们讨论了 PLGA 颗粒的制备以及对颗粒进行各种修饰以使其适用于生物系统的应用。我们强调了新的制备方法，包括微流控和 PRINT 方法，以及对 PLGA 颗粒的修饰，从而产生新颖或响应性的特性，例如 Janus 或上转换颗粒。最后，我们描述了如何根据所需的生物医学应用来调整制备方法，以调整颗粒的特性。我们的目的是使使用 PLGA 颗粒的研究人员更好地理解所选制备程序对颗粒最终性能及其生物学意义的影响。
