Simeonov Marin, Kostova Bistra, Vassileva Elena
Laboratory on Structure and Properties of Polymers, Faculty of Chemistry and Pharmacy, University of Sofia, 1, J. Bourchier blvd., 1164 Sofia, Bulgaria.
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 2, Dunav str., 1000 Sofia, Bulgaria.
Pharmaceutics. 2023 Sep 15;15(9):2328. doi: 10.3390/pharmaceutics15092328.
In this study, a series of novel poly(2-hydroxyethyl methacrylate) (PHEMA)/poly(N,N'-dimethylacrylamide) (PDMAM) interpenetrating polymer networks (IPNs) were synthesized and studied as potential drug delivery systems of dexamethasone sodium phosphate (DXP) for dermal application. The IPN composition allows for control over its swelling ability as the incorporation of the highly hydrophilic PDMAM increases more than twice the IPN swelling ratio as compared to the PHEMA single networks, namely from ~0.5 to ~1.1. The increased swelling ratio of the IPNs results in an increased entrapment efficiency up to ~30% as well as an increased drug loading capacity of DXP up to 4.5%. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show the formation of a solid dispersion between the drug DXP and the polymer (IPNs) matrix. Energy-dispersive X-ray (EDX) spectroscopy shows an even distribution of DXP within the IPN structure. The DXP release follows Fickian diffusion with ~70% of DXP released in 24 h. This study demonstrates the potential of the newly developed IPNs for the dermal delivery of DXP.
在本研究中，合成了一系列新型聚甲基丙烯酸2-羟乙酯（PHEMA）/聚（N，N'-二甲基丙烯酰胺）（PDMAM）互穿聚合物网络（IPN），并作为用于皮肤给药的地塞米松磷酸钠（DXP）潜在药物递送系统进行了研究。IPN的组成允许对其溶胀能力进行控制，因为与PHEMA单一网络相比，高度亲水性的PDMAM的掺入使IPN的溶胀率增加了两倍多，即从约0.5增加到约1.1。IPN溶胀率的增加导致包封效率提高至约30%，以及DXP的载药量增加至4.5%。X射线衍射（XRD）和差示扫描量热法（DSC）表明药物DXP与聚合物（IPN）基质之间形成了固体分散体。能量色散X射线（EDX）光谱显示DXP在IPN结构内分布均匀。DXP的释放遵循菲克扩散，24小时内约70%的DXP被释放。本研究证明了新开发的IPN用于DXP皮肤递送的潜力。
