Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Yunnan University of Chinese Medicine, Kunming, China.
Key Laboratory of Microcosmic Syndrome Differentiation, Yunnan University of Chinese Medicine, Kunming, China.
J Appl Toxicol. 2024 Jun;44(6):798-817. doi: 10.1002/jat.4546. Epub 2023 Sep 27.
Endogenous formaldehyde (FA) is produced in the human body via various mechanisms to preserve healthy energy metabolism and safeguard the organism. However, endogenous FA can have several negative effects on the body through epigenetic alterations, including cancer growth promotion; neuronal, hippocampal and endothelial damages; atherosclerosis acceleration; haemopoietic stem cell destruction and haemopoietic cell production reduction. Certain medications with antioxidant effects, such as glutathione, vitamin E, resveratrol, alpha lipoic acid and polyphenols, lessen the detrimental effects of endogenous FA by reducing oxidative stress, directly scavenging endogenous FA or promoting its degradation. This study offers fresh perspectives for managing illnesses associated with endogenous FA exposure.
内源性甲醛（FA）通过多种机制在人体内产生，以维持健康的能量代谢和保护机体。然而，内源性 FA 可以通过表观遗传改变对身体产生多种负面影响，包括促进癌症生长；神经元、海马和内皮损伤；加速动脉粥样硬化；破坏造血干细胞和减少造血细胞生成。某些具有抗氧化作用的药物，如谷胱甘肽、维生素 E、白藜芦醇、α-硫辛酸和多酚，可以通过减少氧化应激、直接清除内源性 FA 或促进其降解来减轻内源性 FA 的有害影响。本研究为管理与内源性 FA 暴露相关的疾病提供了新的视角。
